Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Facteurs influençant l'implantation d'un programme de prévention universelle de l'anxiété : le cas du programme HORS-PISTE dans les écoles secondaires du Québec. [PDF]
Glob Health PromotLane J +5 more
europepmc +1 more source
Tchaikovsky and his Violin Concerto : A Theme of Opposites [PDF]
, 2000 Bougher, Jennifer Lynn
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Individual and family self-management of genitourinary health in hospitalized men: is there room for intervention by nursing professionals? [PDF]
Rev Esc Enferm USPCosta CA +5 more
europepmc +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Building better outcomes: A grounded theory approach to understanding creation and management of surgical data systems in Ethiopia. [PDF]
PLOS Glob Public HealthJaraczewski TJ +9 more
europepmc +1 more source
Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells
Science, 2013 M. Nieto
semanticscholar +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Supporting families and building relationships: Evaluation of a home and sleep safety equipment scheme for impoverished communities. [PDF]
Public Health Pract (Oxf)Bates J +4 more
europepmc +1 more source