Results 81 to 90 of about 2,665,540 (305)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

An Investigation of Distance Education in North American Research Literature Using Co-word Analysis

open access: yesInternational Review of Research in Open and Distributed Learning, 2010
The field of distance education is composed of a multiplicity of topics leading to a vast array of research literature. However, the research does not provide a chronological picture of the topics it addresses, making it difficult to develop an overview ...
Albert D. Ritzhaupt
doaj  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

A Journey Beyond Reality: Poetic Prose and Lush Imagery in Tanith Lee’s Night’s Master

open access: yesPrague Journal of English Studies, 2016
Tanith Lee was a “highly decorated writer” (Chappell 1) whose work ranged from science-fiction, through fantasy and children’s literature to contemporary and detective novels. Although she published more than ninety novels and three hundred short stories,
Vinczeová Barbora
doaj   +1 more source

Bumper Cars: Themes of Convergence in International Regulation [PDF]

open access: yes, 1992
In this Article, Professor Malloy examines the convergence of regulatory standards among international regulators, suggesting that the dynamic of financial services regulation can be best understood as a conceptualized version of the bumper cars ride at ...
Malloy, Michael P.
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Educação Brasileira: análise temática (1991-1994)

open access: yesTransinformação
Analisei a freqüência de aparecimento dos temas e dos nomes das universidades brasileiras, oficiais e particulares, nos artigos da Revista Educação Brasileira, publicada pelo Conselho de Reitores, no período de 1991 a 1994.
Maria Pia Giazzi Nassri   +2 more
doaj  

Non-Self and Ethics: Kantian and Buddhist Themes [PDF]

open access: yes, 2018
After distinguishing between a metaphysical and a contemplative strategy interpretation of the no-self doctrine, I argue that the latter allows for the illumination of significant and under-discussed Kantian affinities with Buddhist views of the self and
O'Hagan, Emer
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

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