Results 71 to 80 of about 85,619 (248)
Population Pharmacokinetics of Sildenafil in Dogs With Naturally Occurring Pulmonary Hypertension
Journal of Veterinary Pharmacology and Therapeutics, EarlyView.ABSTRACT The pharmacokinetics of sildenafil are ill‐defined in dogs with naturally occurring pulmonary hypertension (PH). Because the plasma concentrations of sildenafil have not been reported for dogs with this disease, this study aimed to describe the population pharmacokinetics of sildenafil in a sample of dogs with PH. Twenty client‐owned dogs with
Mariko Yata +3 more
wiley +1 more source
The MinK Potassium Channel Exists in Functional and Nonfunctional Forms When Expressed in the Plasma Membrane of \u3cem\u3eXenopus\u3c/em\u3e Oocytes [PDF]
, 1994 The minK protein induces a slowly activating voltage-dependent potassium current when expressed in Xenopus oocytes. In order to measure the levels of minK protein in the plasma membrane, we have modified the minK gene by inserting a 9 amino acid epitope ...
Blumenthal, Edward M +1 more
core +1 more source
Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution [PDF]
, 2014 Traditional pharmaceutical dissolution tests determine the amount of drug dissolved over time by measuring drug content in the dissolution medium. This method provides little direct information about what is happening on the surface of the dissolving ...
Fussell, A.L. +4 more
core +3 more sources
Plastid Engineering for Photosynthesis‐Driven Synthesis of Hyaluronic Acid in Tobacco
Plant Biotechnology Journal, EarlyView.ABSTRACT Hyaluronic acid (HA) is a glycosaminoglycan composed of alternating units of N‐acetylglucosamine and glucuronic acid. High moisture retention, viscoelasticity and biocompatibility are unique features that make HA polymers attractive compounds for medical applications and aesthetic purposes.
Amanda Lopes +10 more
wiley +1 more source
New and developing non-adrenoreceptor small molecule drugs for the treatment of asthma [PDF]
, 2017 Introduction: Inhaled corticosteroids (ICS) alone or in combination with an inhaled long-acting beta2-agonist (LABA) are the preferred long-term treatment for adults and adolescents with symptomatic asthma.
Thomson, Neil C.
core +1 more source
Polymorphs of Theophylline Characterized by DNP Enhanced Solid-State NMR
Molecular Pharmaceutics, 2015 We show how dynamic nuclear polarization (DNP) enhanced solid-state NMR spectroscopy can be used to characterize polymorphs and solvates of organic solids. We applied DNP to three polymorphs and one hydrated form of the asthma drug molecule theophylline.
A. Pinon +4 more
semanticscholar +1 more source
Experimental Physiology, EarlyView.Abstract This study examined whether consuming a (poly)phenol‐rich food before strenuous muscle‐damaging exercise can modify post‐exercise markers of inflammation and oxidative stress. Using a double‐blinded, randomised, placebo‐controlled, between‐subjects design, 26 recreationally active males (n = 15) and females (n = 11) consumed higher‐(poly ...
Abrar Al Hebshi +5 more
wiley +1 more source
Anti-phage islands force their target phage to directly mediate island excision and spread. [PDF]
, 2018 Vibrio cholerae, the causative agent of the diarrheal disease cholera, is antagonized by the lytic phage ICP1 in the aquatic environment and in human hosts. Mobile genetic elements called PLEs (phage-inducible chromosomal island-like elements) protect V.
McKitterick, Amelia C, Seed, Kimberley D
core +1 more source
Programming Next‐Generation Synthetic Biosensors by Genetic Circuit Design
Advanced Science, Volume 13, Issue 14, 9 March 2026.Synthetic biology enables genetic circuit‐based biosensing to detect diverse targets, process signals, and transduce them into readable outputs or intracellular regulatory activities. However, field deployment and real‐world application of such synthetic biosensors face considerable challenges in sensitivity, specificity, speed, stability, and ...
Yuanli Gao +4 more
wiley +1 more source
Biofuels, Bioproducts and Biorefining, Volume 20, Issue 2, Page 879-892, March/April 2026.Abstract Guaraná (Paullinia cupana) is a fruit native to the Amazon region. Due to its widespread use, primarily in beverages, its production has grown over the years. The seed is the only commercially valuable part of the fruit so the guaraná production chain generates byproducts, including peel, husk, and spent seed.
Leiliane do Socorro Sodré de Souza +9 more
wiley +1 more source