Results 71 to 80 of about 24,868 (197)

Theophylline and silymarin are potent inhibitors of IL-4 secretion from activated human basophils

American Journal of Experimental and Clinical Research, 2018
Basophils are the most important cells in allergic reactions and secret interleukin 4 (IL-4) and tumor necrosis factor α (TNFα) mediators. Theophylline as a phosphodiesterase 4 inhibitor and silymarin with its anti-inflammatory effects seem to be useful ...
Hamidreza Jahanbani-Ardakani, Ghazale Bordbari, Nahid Eskandari, Ali Mohammad Sabzghabaee, Alireza Andalib   +4 more
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Use of STOPPFrail Medications Following Receipt of the Danish Terminal Grant: A Nationwide Descriptive Study

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 3, September 2026.
Daniel Pilsgaard Henriksen, Thomas Øhlenschlæger, Ann‐Cathrine Dalgaard Dunvald   +2 more
wiley   +1 more source

A Systematic Review of Published Physiologically Based Pharmacokinetic Models for Drug Excretion Into Human Breastmilk: Knowledge Gaps and Opportunities to Optimize Reporting and Modeling Practices

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT Physiologically based pharmacokinetic (PBPK) modeling is increasingly used to predict infant exposure to medications via breast milk. Existing guidance on reporting of PBPK modeling analyses is unstructured and nonbinding to researchers. We evaluated reporting practices and modeling approaches in published PBPK modeling studies.
Joshua Kiptoo, Davies Otieno, Kenta Yoshida, Neel Deferm, Aida Nakayiwa Kawuma, Francis Williams Ojara, Adeniyi Olagunju, Jackson K. Mukonzo, Catriona Waitt   +8 more
wiley   +1 more source

Comparison between theophylline, N-acetylcysteine, and theophylline plus N-acetylcysteine for the prevention of contrast-induced nephropathy

ARYA Atherosclerosis, 2015
BACKGROUND: Few studies compared the efficacy of theophylline with N-acetylcysteine or evaluated the efficacy of combination therapy in the prevention of contrast-induced nephropathy (CIN).
Morteza Arabmomeni, Jamshid Najafian, Morteza Abdar Esfahani, Mohsen Samadi, Leila Mirbagher   +4 more
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Dissociated Biologic Responses Across the United Airway: A Case Report of Severe Asthma With Chronic Rhinosinusitis With Nasal Polyps and Eosinophilic Otitis Media

Respirology Case Reports, Volume 14, Issue 8, August 2026.
We report a case of severe asthma with chronic rhinosinusitis with nasal polyps and eosinophilic otitis media that was successfully controlled by switching biologic therapy from dupilumab to mepolizumab. Careful monitoring of disease activity and consideration of biologic switching may help achieve optimal control with currently available biologics ...
Tomoko Tajiri, Naoki Takemoto, Toshiya Minakata, Motohiko Suzuki, Yoshiyuki Ozawa, Hirotsugu Ohkubo   +5 more
wiley   +1 more source

Electrochemical Determination of Theophylline Pharmacokinetic under the Effect of Roxithromycin in Rats by the MWNTs/Au/poly-L-lysine Modified Sensor

International Journal of Electrochemical Science, 2017
In this work, a novel and simple method for pharmacokinetic of theophylline in rats was described with modified sensor based on MWNTs/Au/poly-L-lysine.
Anlin Peng, Hong Yan, Caikui Luo, Guangxian Wang, Yuting Wang, Xianzhi Ye, Hong Ding   +6 more
doaj   +1 more source

Effect of molecular perturbation on cocrystal formation: theophylline and its 8‐halo analogues with flavonoids

Acta Crystallographica Section C, Volume 82, Issue 8, Page 414-426, August 2026.
The tendency for alkaloid–flavonoid cocrystal formation is found to be markedly different for theophylline (Tph) compared to its 8‐halo analogues. Through screening with 13 common flavonoids, Tph is found to form cocrystals with six flavonoids, whereas 8‐Cl‐Tph and 8‐Br‐Tph each form cocrystals with just two, myricetin and kaempferol.
Weijian Ye, Herman H-Y. Sung, Ian D. Williams   +2 more
wiley   +1 more source

Reconsidering Molecular Docking Practices in Aptamer Research

ChemBioChem, Volume 27, Issue 14, 29 July 2026.
Benchmarking against the theophylline aptamer crystal structure shows that current docking workflows generate incorrect structures and fail to predict binding specificity, underscoring the need for caution when interpreting docking results in aptamer research. Molecular docking is increasingly used to infer aptamer–target interactions, yet most studies
Yachen Xie, Juewen Liu
wiley   +1 more source

Oligonucleotides Post‐Synthetic Modifications: An Overview of Clickable Nucleoside Phosphoramidites Suitable for Solid‐Phase Synthesis

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Clickable nucleoside phosphoramidites can be incorporated into oligonucleotides via solid‐phase synthesis (SPOS), enabling rapid and site‐specific post‐functionalization using bioorthogonal reactions. This review highlights their design, synthetic accessibility, and SPOS incorporation requirements, along with the kinetics and efficiency of post ...
Sébastien Depienne, Alexandra Bristiel, Dominique Urban, Dominique Guianvarc’h   +3 more
wiley   +1 more source

Doxofylline is not just another theophylline!

International Journal of COPD, 2017
Maria Gabriella Matera,1 Clive Page,2 Mario Cazzola3 1Department of Experimental Medicine, Unit of Pharmacology, University of Campania ‘Luigi Vanvitelli’, Naples, Italy; 2Sackler Institute of Pulmonary Pharmacology, Institute of ...
Matera MG, Page C, Cazzola M
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