Results 61 to 70 of about 3,746,779 (357)
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
What is critical for human-centered AI at work? – Toward an interdisciplinary theory
Frontiers in Artificial Intelligence, 2023 Human-centered artificial intelligence (HCAI) has gained momentum in the scientific discourse but still lacks clarity. In particular, disciplinary differences regarding the scope of HCAI have become apparent and were criticized, calling for a systematic ...
Athanasios Mazarakis +3 more
doaj +1 more source
The place of expert systems in a typology of information systems [PDF]
, 1986 This article considers definitions and claims of Expert Systems ( ES) and analyzes them in view of traditional Information systems (IS). It is argued that the valid specifications for ES do not differ fran those for IS. Consequently the theoretical study
Simons, J.L., Wieringa, R.J.
core +2 more sources
Practice-oriented controversies and borrowed epistemic credibility in current evolutionary biology: phylogeography as a case study [PDF]
, 2013 Although there is increasing recognition that theory and practice in science are intimately intertwined, philosophy of science perspectives on scientific controversies have been historically focused on theory rather than practice.
Arroyo-Santos, Alfonso +2 more
core +3 more sources
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Unsharp Values, Domains and Topoi [PDF]
, 2011 The so-called topos approach provides a radical reformulation of quantum theory. Structurally, quantum theory in the topos formulation is very similar to classical physics.
Barbosa, Rui Soares, Doering, Andreas
core +1 more source
Good Usability Practices in Scientific Software Development [PDF]
, 2017 Scientific software often presents very particular requirements regarding usability, which is often completely overlooked in this setting. As computational science has emerged as its own discipline, distinct from theoretical and experimental science, it has put new requirements on future scientific software developments.
arxiv +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Interactive game as a means of developing extracurricular activities in informatics
RUDN Journal of Informatization in Education, 2019 Problem and goal. The article describes the processes of development of methods of teaching computer science in the organization of extracurricular activities, which contributes to the effectiveness of teaching computer science through the use of games ...
Olga Yu. Zaslavskaya
doaj +1 more source
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
FEBS Letters, EarlyView.The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt +8 more
wiley +1 more source