Results 71 to 80 of about 4,222,853 (324)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Complexity of the Basic Reproduction Number (R0)

Emerging Infectious Diseases, 2019
The basic reproduction number (R0), also called the basic reproduction ratio or rate or the basic reproductive rate, is an epidemiologic metric used to describe the contagiousness or transmissibility of infectious agents.
Paul L. Delamater, Erica J. Street, Timothy F. Leslie, Y. Tony Yang, Kathryn H. Jacobsen   +4 more
doaj   +1 more source

Financial correlations at ultra-high frequency: theoretical models and empirical estimation

, 2011
A detailed analysis of correlation between stock returns at high frequency is compared with simple models of random walks. We focus in particular on the dependence of correlations on time scales - the so-called Epps effect.
A. Lo, A. Lo, A. Zebedee, B. Tóth, B. Tóth, B. Tóth, B. Tóth, C. Borghesi, G. Bonanno, I. Mastromatteo, J. Muthuswamy, J.E. Griffin, L. Kullmann, L. Zhang, M. Marsili, M. Potters, M. Scholes, M.C. Munnix, M.C. Munnix, P. Malliavin, P. Zoi, R. Renò, S. Pafka, T. Hayashi, T.W. Epps   +24 more
core   +2 more sources

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Computational studies of biomembrane systems: Theoretical considerations, simulation models, and applications

, 2013
This chapter summarizes several approaches combining theory, simulation and experiment that aim for a better understanding of phenomena in lipid bilayers and membrane protein systems, covering topics such as lipid rafts, membrane mediated interactions ...
Deserno, Markus, Kremer, Kurt, Paulsen, Harald, Peter, Christine, Schmid, Friederike   +4 more
core   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

EVOLUCIÓN DE INTERACCIONES PARÃ�SITO - HOSPEDERO: COEVOLUCIÓN, SELECCIÓN SEXUAL Y OTRAS TEORÃ�AS PROPUESTAS THE EVOLUTION OF HOST-PARASITE INTERACTIONS: COEVOLUTION, SEXUAL SELECTION AND OTHER SUGGESTED THEORIES

Revista U.D.C.A Actualidad & Divulgación Científica, 2011
Esta revisión resume los modelos teóricos de interacciones parásito-hospedero que se encuentran disponibles en la literatura científica. Se revisaron publicaciones internacionales en revistas especializadas sobre parasitología y ecología.
Guillermo Rico-Hernández
doaj  

Theoretical Models for Producing Circularly Polarized Radiation in Extragalactic Radio Sources

, 2003
We discuss the production of circular polarization in compact radio sources both by the intrinsic mechanism and by Faraday conversion. We pay particular attention to the magnetic field structure, considering partially ordered fiel ds and Laing sheets ...
Homan, Daniel C., Wardle, John F. C.
core   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source