Results 41 to 50 of about 369,917 (259)
Determining Parental Factors for Clinical Trial Attrition in Pediatric Acute Lymphoblastic Leukemia
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background/Objectives Despite high enrollment rates on Children's Oncology Group (COG) protocols, attrition after initial consent is challenging, introducing bias and prolonging trial completion. While adult oncology literature has identified predictors of withdrawal, little is known about caregiver decision‐making for child participation in ...
Kimberly L. Stathas +3 more
wiley +1 more source
For a Dialectic-First Approach to Kant’s Critique of Pure Reason
Open Philosophy, 2022 To judge by the title, one would expect that interpretations of the Critique of Pure Reason would prioritize the division of the book most about reason and its critique: The Transcendental Dialectic.
Kreines James
doaj +1 more source
Reasoning about Action: An Argumentation - Theoretic Approach
Journal of Artificial Intelligence Research, 2005 We present a uniform non-monotonic solution to the problems of reasoning about action on the basis of an argumentation-theoretic approach. Our theory is provably correct relative to a sensible minimisation policy introduced on top of a temporal propositional logic. Sophisticated problem domains can be formalised in our framework.
Vo, Bao Quoc, Foo, Norman Y.
openaire +4 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
THEORETICAL AND IDEOLOGICAL SOURCES OF IBN SINA PHILOSOPHY ON THE ISSUE OF REASON AND FAITH
Sovremennye Issledovaniâ Socialʹnyh Problem, 2015 The article examines the theoretical and ideological sources of Ibn Sina philosophy on the issue of human. The author emphasizes that the studies of Ibn Sina were based on the philosophical tradition of antiquity, on their doctrine of man as a rational ...
Saida Zakhro Takikhoni
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
The problem of antinomy of pure theoretical reason in Kant’s system [PDF]
Кантовский сборник, 2014 A thorough analysis of the structure of the treatise constituting the first Critique and its comparison with the analogous structure of the second and third Critiques show that the Critique of Pure Reason lacks such an important element as the antinomy ...
Kalinnikov L.
doaj
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The role and place of reason in justifying religious beliefs from the perspective of Allameh Tabatabai and Thomas Aquinas [PDF]
تاریخ فلسفه اسلامیAllameh considers the intellect to be the soul of human evidence, and the heart is the soul of evidence, thus the receiver of revelation; Self is evidence and it is referred to as heart or intellect.
Mohsen Izadi, Amir Mahdi Shiri
doaj +1 more source