Results 41 to 50 of about 5,773,252 (243)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Kant on the Unity of Theoretical and Practical Reason [PDF]
, 1998 In his critical works of the 1780's, Kant claims, seemingly inconsistently, that (1) theoretical and practical reason are one and the same reason, applied differently, (2) that he still needs to show that they are, and (3) that theoretical and practical ...
Kleingeld, Pauline
core +3 more sources
The problem of antinomy of pure theoretical reason in Kant’s system [PDF]
Кантовский сборник, 2014 A thorough analysis of the structure of the treatise constituting the first Critique and its comparison with the analogous structure of the second and third Critiques show that the Critique of Pure Reason lacks such an important element as the antinomy ...
Kalinnikov L.
doaj
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
The role and place of reason in justifying religious beliefs from the perspective of Allameh Tabatabai and Thomas Aquinas [PDF]
تاریخ فلسفه اسلامیAllameh considers the intellect to be the soul of human evidence, and the heart is the soul of evidence, thus the receiver of revelation; Self is evidence and it is referred to as heart or intellect.
Mohsen Izadi, Amir Mahdi Shiri
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Revista de Filosofia, 2014 The aim of the article is to evaluate to what point does Husserl’s first insight into affective consciousness manage to extend the concept of “reason” to this sphere and analyses whether the way this is accomplished threatens its autonomy regarding ...
Celia Cabrera
doaj +1 more source
Paradigmatic Ideas in the Critique of Historical Reason in Islam [PDF]
تاریخ نگری و تاریخ نگاری, 2018 If we accept that any interpretation of the Islamic heritage of thought is based on a framework of ideas and concepts, which is the title of historical reason, then the continuation of the structure of this historical reason leads to the ineffectiveness ...
Abdolah Motevaly +2 more
doaj +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source