Results 41 to 50 of about 142,592 (267)

On the Way to a Theory for Network Architectures [PDF]

open access: yes, 2010
The design of the future Internet is facing real challenges on network architecture. Attempts to resolve the issues related to naming/addressing, middle boxes, QoS-Security-Mobility interactions, cross-layer and inter-domain usually lead to endless debates.
openaire   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

An overview and evaluation of urban villas in Sarajevo built between the world wars [PDF]

open access: yesZbornik Radova Filozofskog Fakulteta u Prištini
The purpose of this paper is to provide an overview of the typology of the urban villas constructed in Sarajevo in the first half of the 20th century, which are considered worth preserving as part of Bosnia and Herzegovina's significant architectural ...
Kahrović-Handžić Lejla   +2 more
doaj   +1 more source

Reshaping Publicness: Research on Correlation between Public Participation and Spatial Form in Urban Space Based on Space Syntax—A Case Study on Nanjing Xinjiekou

open access: yesBuildings, 2022
This paper focuses on urban regeneration practices in central urban areas, aiming to find key points for reshaping the publicness of urban spaces by exploring the morphological features of public spaces and the spatial distribution patterns of public ...
Mengyao Pan   +4 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

A cidade ideal

open access: yesIn_Bo, 2020
A perspective animated of monuments, in which iconic architectures are melted in a summa of urban models designed, imagined, sometimes ephemeral, often desired.
Ana Aragão
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

The Problem of Attitudes towards History in the Theory of Architecture of Postmodernism

open access: yesAcademia: Архитектура и строительство, 2019
The article contains a study of changes in the attitude to history in the foreign architecture of the twentieth century, in connection with the radical transformation of the perception of categories of time.
Alexey A. Khudin
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

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