Results 61 to 70 of about 131,886 (266)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Modernistinės estetikos apraiškos tarpukario Lietuvos architektūrinėje mintyje

Journal of Architecture and Urbanism, 2010
The paper focuses on the origin of Lithuanian Modern architecture during the interwar period and analyses an emerging phenomenon of architectural criticism and theory.
Vaidas Petrulis
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Systematisation of techniques for a holistic solution to reducing the vulnerability of coastal areas to water level fluctuations

Budownictwo i Architektura
The article examines the issue of a holistic solution for reducing the vulnerability of coastal urban areas to water level fluctuations. Based on an analysis of examples from global, French, and Ukrainian practice, it generalises and proposes an ...
Nellya Leshchenko, Hanna Dorokhina, Anhelina Busel , Marina Shyrokobokova   +3 more
doaj   +1 more source

Vivid agents: Theory, architecture, and applications

Applied Artificial Intelligence, 2000
Vivid agents (Wagner, 1996) are software-controlled systems whose state comprises the mental components of knowledge, perceptions, tasks, and intentions, and whose behavior is represented by means of action and reaction rules. An execution model for vivid agents is presented, which is based on an architecture for concurrent action and planning (CAP ...
Michael Schroeder 0001, Gerd Wagner 0001
openaire   +2 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

The importance of multi-roles and code-switching in living labs

Buildings & Cities
The challenges and opportunities for multi-roles in participatory urban development projects are investigated. An analysis of bottom-up initiatives in two living labs in Germany: Quartier:PLUS (Braunschweig) and Österreichischer Platz (Stuttgart ...
Hanna Noller, Ayat Tarik
doaj   +1 more source

Architectural Felicitology

Проект Байкал, 2015
The article features the meaning of the category “happiness” applied in the architectural theory. The author suggests a connection between a new explication of “happiness” in architecture and the categories “own place”, “close human relations” and ...
Alexander Rappaport
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source