Results 41 to 50 of about 109,411 (311)

Constraints based scheduling in the multi-project environment

Computer Assisted Methods in Engineering and Science, 2022
The paper deals with the problem of new projects acceptance into the multi project environment, where constraints are limiting the number of projects that a company is able to carry out concurrently. The objective of this paper is to answer the question:
Bożena Skołud, Aleksandra Zientek
doaj  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The Soft Budget Constraint: A Theoretical Clarification [PDF]

In this paper, we have distinguished three different conceptions of the budget constraint (BC). The first one, introduced by Clower, regards the BC as a universal (unconditional) rational planning postulate.
Mehrdad Vahabi
core   +2 more sources

Defence Entrepreneurship: A Theory of Military Innovation Under Constraint

Revista Científica General José María Córdova
This article advances defence entrepreneurship as an analytical category to address a gap in military innovation studies, which privilege structural and systemic explanations while underspecifying the intentional action of actors who force change under ...
Pascal Carlucci
doaj   +1 more source

Computational Constraints in Cognitive Theories of Forgetting [PDF]

Frontiers in Psychology, 2012
This article highlights some of the benefits of computational modeling for theorizing in cognition. We demonstrate how computational models have been used recently to argue that (1) forgetting in short-term memory is based on interference not decay, (2) forgetting in list-learning paradigms is more parsimoniously explained by a temporal distinctiveness
Ecker, Ullrich K H, Lewandowsky, Stephan
openaire   +4 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The Second Parameter in J.-R. Curves: Constraint or Triaxiality

, 2022
S.209-231J-R curves are used to assess the stability of growing cracks in ductile materials. Since initiation and crack-extension resistance are geometry dependent any transfer of the measured data to a structural omponent is subject to the individual ...
Brocks, W., Schmitt, W.
core  

Deciding equivalence-based properties using constraint solving [PDF]

, 2013
Formal methods have proved their usefulness for analyzing the security of protocols. Most existing results focus on trace properties like secrecy or authentication.
Véronique Cortier, Stéphanie Delaune, Cheval, Vincent, Delaune, Stéphanie, Vincent Cheval, Cortier, Véronique   +5 more
core   +1 more source