Results 61 to 70 of about 109,411 (311)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Jixie chuandong, 2018 The screw theory is adopted to analyze the constraint of planar mechanisms branch link on mobile platform,the redundant constraint and partial degree of freedom of mechanism is found out,and the formula of degree of freedom is modified,the mobility of ...
Zhang Yan +4 more
doaj
Dynamic modeling of SCARA robot based on Udwadia–Kalaba theory
Advances in Mechanical Engineering, 2017 With the aim of dynamic modeling of the SCARA robot subjected to space trajectory constraint to satisfy repetitive tasks with higher accuracy, a succinct and explicit equation of motion based on Udwadia–Kalaba theory is established.
Yaru Xu, Rong Liu
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Optimization two-qubit quantum gate by two optical control methods in molecular pendular states
Scientific Reports, 2022 Implementation of quantum gates are important for quantum computations in physical system made of polar molecules. We investigate the feasibility of implementing gates based on pendular states of the molecular system by two different quantum optical ...
Jin-Fang Li +3 more
doaj +1 more source
Cosmological Constraints on Brans-Dicke Theory [PDF]
Physical Review Letters, 2014 We report strong cosmological constraints on the Brans-Dicke (BD) theory of gravity using Cosmic Microwave Background data from Planck.We consider two types of models. First, the initial condition of the scalar field is fixed to give the same effective gravitational strength $G_{eff}$ today as the one measured on the Earth, $G_N$.
Avilez, A. +3 more
openaire +4 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
HOW HAS OPTIMALITY THEORY ACHIEVED THE GOALS OF LINGUISTIC THEORY
مجلة الآداب, 2015 Optimality Theory (OT) is a grammatical framework of recent origin presented by Prince and Smolensky in 1993. The central idea of Optimality Theory is that surface forms of language reflect resolutions of conflicts between competing constraints.
Israa .B Abdurrahman
doaj +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source