Results 51 to 60 of about 109,411 (311)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

The Workplace Dilemma: Examining the Effects of Work-Related Constraints on Travel Decision-Making

open access: yesTourism and Hospitality
Work-related constraints significantly hinder individuals’ ability to engage in leisure travel, impacting mental health and work–life balance. This study investigates the influence of work-related travel constraints on travel intentions using the Theory ...
Saerom Wang
doaj   +1 more source

Characterization of Noncontextuality in the Framework of Generalized Probabilistic Theories

open access: yesPRX Quantum, 2021
To make precise the sense in which the operational predictions of quantum theory conflict with a classical worldview, it is necessary to articulate a notion of classicality within an operational framework.
David Schmid   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

IDENTIFIKASI RESOURCES CONSTRAINT PADA KINERJA PELAYANAN DENGAN PENDEKATAN THEORY OF CONSTRAINT DI INSTALASI RAWAT INAP RSU HAJI SURABAYA

open access: yesThe Indonesian Journal of Public Health, 2019
The trend of Gross Death Rate (GDR) Surabaya Hajj Hospital had tended to increase from 2012 to 2015.However, it eventually decreased in 2016. This research aims to analyze the constraints in the service performance at the inpatient unit of Surabaya Hajj ...
Vida Indira Puspita, Setya Haksama
doaj   +1 more source

On a differential constraint in the continuum theory of growing solids

open access: yesVestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2019
The present paper is devoted to the problem of boundary conditions formulation for asymmetric problems in the mechanics of growing solids (MGS). The boundary conditions on the propagating growing surface (PGS) is the fundamental problem of this branch ...
Eugenii Valeryevich Murashkin   +1 more
doaj   +3 more sources

Type Synthesis of 4-DOF Non-Overconstrained Parallel Mechanisms with Symmetrical Structures

open access: yesMachines, 2022
This paper presents the type synthesis of 4-DOF non-overconstrained parallel mechanisms (PMs) with symmetrical structures. A special topological structure that includes two intermediate platforms and one moving platform is employed. Constraint conditions
Wei Ye, Qinchuan Li, Xinxue Chai
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Constraints on theories of cognitive aging [PDF]

open access: yesPsychonomic Bulletin & Review, 1996
There is currently little consensus regarding what must be explained by theories of cognitive aging. In the present article, four empirical generalizations that seem to imply certain constraints in theorizing are identified. These generalizations, and their possible implications or constraints, are that (1) age-related differences are found in a wide ...
openaire   +2 more sources

A theory of dynamic contracting with financial constraints [PDF]

open access: yesJournal of Economic Theory, 2016
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Ilia Krasikov, Rohit Lamba
openaire   +2 more sources

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