Results 41 to 50 of about 166,378,206 (284)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Machine learning-assisted fracture prediction: Integrating synthetic and experimental data for quasi-static notch failure analysis

Fracture and Structural Integrity
Machine learning has emerged as a powerful tool in various scientific fields for developing data-driven models, reducing the need for extensive physical testing.
Sheikh Aamir Farooq, Danah Alajaleen, Jafar Albinmousa   +2 more
doaj   +3 more sources

Mixed-mode fracture of notched AW 2099-T83 Al-Li Alloy: Effects of inclination angle and stress triaxiality

Results in Engineering
Third-generation aluminum-lithium alloys such as AW 2099-T83 offer attractive properties for aerospace applications, including low density, high stiffness, and excellent fracture toughness.
Jafar Albinmousa
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Critical Race Theory (EducationWeek Spotlight)

, 2021
A collection of short articles that explain the controversy over "critical race theory" in education that arose in 2020 and 2021. Titles include: "What Is Critical Race Theory, and Why Is It Under Attack?"; "Critical Race Theory Isn’t a Curriculum. It’s
Schwartz, Sarah, George, Janel, Pendharkar, Eesha, Ujifusa, Andrew, Sawchuck, Stephen   +4 more
core  

Statistical properties of threshold and notch derived estimations of the critical distance according to the line method of the theory of critical distances

International Journal of Fatigue, 2020
Abstract The theory of critical distances is based on the definition of a material-dependent length L. Here, we investigate the statistical properties of L deduced from the crack threshold or a suitable notched specimen geometry. Monte Carlo simulations are done for best-fitting analytical functions to express mean, standard deviation and skewness of
Benedetti M., Santus C.
openaire   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Critical race theory FAQ

, 2021
Once an obscure academic concept, the term critical race theory (CRT) has become a regular fixture in mainstream media and social media as well as local school board meetings.

core  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source