Results 91 to 100 of about 563,485 (262)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Federated or Non-Federated Sports: The Influence on Children, the Youth Population and Family Life

Education Sciences
Family time must be combined with the personal time of each of its members, with special importance regarding children due to the need for attention and monitoring by parents of their performance.
José Santiago Álvarez Muñoz, Mª Ángeles Hernández Prados, César Palazón Segura   +2 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Design, Analysis and Experiment of a Modular Deployable Continuum Robot

Machines
Continuum robots, possessing great flexibility, can accomplish tasks in complex work scenes, regarded as an important direction in robotics. However, the current continuum robots are not satisfying enough in terms of fabrication and maintenance, and ...
Aihu Jia, Xinyu Liu, Yuntao Guan, Yongxi Liu, Qianze Helian, Chenshuo Liu, Zheming Zhuang, Rongjie Kang   +7 more
doaj   +1 more source

Vocational and Liberal Education in Pestalozzi’s Educational Theory

Pedagogía y Saberes, 2019
Johann Heinrich Pestalozzi’s most popular catchphrase “head, heart, and hand” implies the concept of a holistic combination of all human capabilities as a well-balanced development of intellectual, religious-emotional and physical forces enabled by education.
openaire   +5 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Tool wear influence on surface roughness, burrs and cracks in milling unidirectional carbon fiber reinforced plastics (UD-CFRP)

Journal of Materials Research and Technology
This study delves into the machining defects encountered during the milling of Carbon Fiber Reinforced Plastics (CFRP), with a special focus on fishbone-like cracks on the machined surface, which have never been focused before.
Weizhou Wu, Shipeng Li, Xuda Qin, Guoyu Fu, Zhengwei Bao, Hao Li, Qing Zhao   +6 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Assessment of GreenComp learning in the training of education professionals

Frontiers in Education
IntroductionThe European Green Pact outlines various actions to promote awareness and learning about environmental sustainability. It highlights the European Framework of Competences for Sustainability (GreenComp), which is to be introduced in ...
M. Pilar Martínez-Agut, Anna Monzó-Martínez, Eva Ortiz-Cermeño   +2 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source