Results 141 to 150 of about 152,877 (259)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
, 2009 Book description: This volume offers an integrative approach to the application of evolutionary theory in studies of cultural transmission and social evolution and reveals the enormous range of ways in which Darwinian ideas can lead to productive ...
Venti, J, Lake, MW
core
String field theoryะ Time evolution and T-duality [PDF]
, 2005 The time evolution operator of quantum field theory (Schrödinger functional) can be written in terms of particles moving on S(^1)/Z(_2-). By deriving the 'gluing property’ which joins two propagators across fixed time surfaces, we show that the Feynman ...
Liderton, Anton
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
The Descent of Milman: A Darwinian Reading of Parry on the Homeric Formula
History of Classical ScholarshipThe opposition of synchrony to diachrony represents a false dichotomy for understanding Parry’s work, for, like Darwin before him, he sought to reconstruct from the present state of the evidence historical developments (in his case the oral, formulaic ...
R. Drew Griffith
doaj
A Neo-Darwinian Foundation of Evolutionary Economics. With an Application to the Theory of the Firm. [PDF]
The focus of evolutionary economics is a process of continuous economic and organizational change. Currently there is no agreement on the explanation of economic evolution. Rather there are competing interpretations.
Fritz Rahmeyer
core
The evolution of sex [Principles of evolution, ecology and behavior]
, 2016 Educação Superior::Ciências Biológicas::GenéticaPresents a class of Professor Stephen Stearns that talks about the evolution of sex. He explains it's evolution and continued prevalence. He argues that sex does have several costs compared to asex, but the
Stearns, Stephen C.
core +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source