Results 151 to 160 of about 152,877 (259)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Taming the Savage: The 19th-Century Theistic Evolutionists on Children and Education
Социология властиThe aim of the paper is to analyze the positions on children and education expressed in the writings of the 19th-century theistic evolutionists in the general context of the history of evolutionary thought. Theistic evolutionists considered evolution not
Alexander V. Khramov
doaj
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
HTS Teologiese Studies/Theological Studies, 2016 This article addresses the issue of human imagination from the perspective of ‘niche construction’ in the wider discussion about ‘what makes us human’ and what it means to be a ‘self’, specifically for the Christian faith and for theology. In the article,
J. Wentzel Van Huyssteen
doaj
The evolution of mixed strategies in population games
, 2008 We study the evolution of mixed strategies in population games. At any time, the distribution of mixed strategies over agents in a population is described by a density function. A pair of players is chosen randomly in each round of the game. After each
Lahkar, R., Seymour, R.
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
DARWIN'S IMPACT: SOCIAL EVOLUTION IN AMERICA, 1880-1920
, 2001 VOLUME 1 Introduction / Rick Tilman -- Bibliography / Frank X. Ryan -- Ch. I. The social Darwinists: Sumner and his successors -- "On the reasons why man is not altogether a brute" in "What social classes owe to each other" (1883) / William Graham ...
Ryan, Frank X., ed.
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