Results 41 to 50 of about 643,680 (254)
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Teoria cunoștinței: Angajamentele epistemologice tacite ale lui Nicolae Bagdasar
Studii de Istorie a Filosofiei Româneşti, 2021 Through the filter of his specific two steps method in approaching theories of knowledge, Bagdasar seems to invite his interpreter to consider solely the systematic level.
Marius Augustin Drăghici
doaj
Scrutinizing the Smart City Index: a multivariate statistical approach [PDF]
Zbornik radova Ekonomskog fakulteta u Rijeci : časopis za ekonomsku teoriju i praksu, 2019 The smart city represents a frequently elaborated concept which however comes short in delivering a consistent definition. Nevertheless, almost every description has always been oriented to its technological component, sustainable ...
Olga Bogdanov +3 more
doaj +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
About some aspects of D.I. Mendeleev's world-outlook
Тонкие химические технологии, 2009 In this paper, the section «World outlook» of D.I. Mendeleev's book «Cherished Thoughts» is analyzed. It is shown, what, in Mendeleev's opinion, is the connection between philosophy and science, how important the problem was for him.
A. A. Ivanova
doaj
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Le sens de l’être. Heidegger et le néokantisme
Methodos, 2004 It is argued, that Neokantianism – often criticized polemically by Heidegger and his followers –, especially the Neokantianism of his teacher Heinrich Rickert, presents a more thorough theory concerning the fundaments of human understanding than ...
Christian Krijnen
doaj +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
On the possibility of transmitting the fieldwork experience: Presentation of the meta-methodological conditions of the transitional fieldwork [PDF]
Glasnik Etnografskog Instituta SANU, 2010 Without any intention to synthesize the broader theoretical discussions about the problem, I shall herein try to outline the boundaries of “the fieldwork”, as an implied, disputed, but also inevitable ethnologic scientific practice.
Prica Ines
doaj +1 more source