Results 61 to 70 of about 5,516,066 (291)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Knowledge-First Theories of Justification [PDF]
, 2020 Knowledge-first theories of justification give knowledge priority when it comes to explaining when and why someone has justification for an attitude or an action. The emphasis of this entry is on knowledge-first theories of justification for belief.
Silva, Paul
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
On the possibility of transmitting the fieldwork experience: Presentation of the meta-methodological conditions of the transitional fieldwork [PDF]
Glasnik Etnografskog Instituta SANU, 2010 Without any intention to synthesize the broader theoretical discussions about the problem, I shall herein try to outline the boundaries of “the fieldwork”, as an implied, disputed, but also inevitable ethnologic scientific practice.
Prica Ines
doaj +1 more source
, 2011 This paper examines the causal theory of knowledge put forth by Alvin Goldman in his 1967 paper “A Causal Theory of Knowing.” Goldman contends that a justified, true belief is knowledge if and only if it is causally connected to the fact that ...
Stalkfleet, Kenneth
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Tetens et la philosophie transcendantale : introduction
Astérion, 2018 Imagine an author living in the days of Kant, who influenced him, but at the same time followed his own path... Imagine that this author criticized some phases of Kantian thought, developing an original approach to issues as important as objectivity, or ...
Jean-Paul Paccioni
doaj +1 more source
Humanoid Theory Grounding [PDF]
, 2001 In this paper we consider the importance of using a humanoid physical form for a certain proposed kind of robotics, that of theory grounding. Theory grounding involves grounding the theory skills and knowledge of an embodied artificially intelligent (AI)
Mislivec, Eric J. +1 more
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Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source