Results 51 to 60 of about 168,933,403 (296)

Scrutinizing the Smart City Index: a multivariate statistical approach [PDF]

open access: yesZbornik radova Ekonomskog fakulteta u Rijeci : časopis za ekonomsku teoriju i praksu, 2019
The smart city represents a frequently elaborated concept which however comes short in delivering a consistent definition. Nevertheless, almost every description has always been oriented to its technological component, sustainable ...
Olga Bogdanov   +3 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Le sens de l’être. Heidegger et le néokantisme

open access: yesMethodos, 2004
It is argued, that Neokantianism – often criticized polemically by Heidegger and his followers –, especially the Neokantianism of his teacher Heinrich Rickert, presents a more thorough theory concerning the fundaments of human understanding than ...
Christian Krijnen
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Subjectivity and Reflexivity in the Social Sciences: Epistemic Windows and Methodical Consequences

open access: yesForum: Qualitative Social Research, 2003
We sketch four basic epistemological assumptions that imply a constructionist orientation to knowledge including (a) perspectivity, positionality; (b) horizonality, dynamic observer position; (c) the structuring of knowledge through instruments of ...
Franz Breuer
doaj  

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Self-knowledge: a study of Sartre and Hampshire [PDF]

open access: yes, 1988
This work examines some of the epistemological and ontological conditions of the deep self-knowledge that is demanded by the Delphic motto gnothi seauton (know thyself!). The guiding questions are: what is the 'self' that deep self-knowledge is of?
Jopling, David A., Jopling, D.A
core   +1 more source

On the possibility of transmitting the fieldwork experience: Presentation of the meta-methodological conditions of the transitional fieldwork [PDF]

open access: yesGlasnik Etnografskog Instituta SANU, 2010
Without any intention to synthesize the broader theoretical discussions about the problem, I shall herein try to outline the boundaries of “the fieldwork”, as an implied, disputed, but also inevitable ethnologic scientific practice.
Prica Ines
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

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