Results 71 to 80 of about 5,516,066 (291)

A SHANNON'S THEORY OF KNOWLEDGE [PDF]

, 2007
Our so-called “Information Society” is gradually changing into a “Knowledge Society”. The Shannon's Theory provided a formal and mathematical framework for information. It was very fruitful for avoiding ambiguity on the concept of information. This paper proposes a transposition of this theory for knowledge.
Benoît Le Blanc, Jean-Louis Ermine
openaire   +4 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

The Ontology of Knowledge, logic, arithmetic, sets theory and geometry (issue 20210304) [PDF]

, 2021
In Issue 20210304 the paragraph "intuition of space" is reworded/improved. At ordinary scales, the ontological model proposed by Ontology of Knowledge (OK) does not call into question the representation of the world elaborated by common sense ...
Boucon, Jean-Louis
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Subjectivity and Reflexivity in the Social Sciences: Epistemic Windows and Methodical Consequences

Forum: Qualitative Social Research, 2003
We sketch four basic epistemological assumptions that imply a constructionist orientation to knowledge including (a) perspectivity, positionality; (b) horizonality, dynamic observer position; (c) the structuring of knowledge through instruments of ...
Franz Breuer
doaj  

From Platonic anamnesis to the architectonics of philosophical knowledge: The historical-philosophical status of reminiscence [PDF]

Известия Саратовского университета. Новая серия: Серия Философия. Психология. Педагогика
Introduction. The article explores the phenomenon of reminiscence as a possible method of constructing the history of philosophy, which transforms the Platonic concept of recollection (anamnesis) into a tool for synthesizing universal ideas and ...
Romaschenko, Maria A., Romashchenko, Alexander Alexandrovich   +1 more
doaj   +1 more source

A Shannon's theory of knowledge [PDF]

Our so-called "Information Society", is gradually changing into a "Knowledge Society". The Shannons Theory provided a formal and mathematical framework for information. It was very fruitful for avoiding ambiguity on the concept of information. This paper
Benoît Le Blanc, Jean-Louis Ermine
core  

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source