Results 71 to 80 of about 168,933,403 (296)

Ce este și cum poate fi cunoscut datul. Comentariu pe marginea capitolului despre pozitivism din Teoria cunoștinței

open access: yesStudii de Istorie a Filosofiei Româneşti, 2021
In Teoria cunoștinței (Theory of knowledge), the author N. Bagda­sar enunciated the following idea: the metaphysics is conditioned by the theory of knowledge, since the first is a knowledge placed from the beginning under rules.
Viorel Cernica
doaj  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

open access: yesFEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay   +2 more
wiley   +1 more source

About some aspects of D.I. Mendeleev's world-outlook

open access: yesТонкие химические технологии, 2009
In this paper, the section «World outlook» of D.I. Mendeleev's book «Cherished Thoughts» is analyzed. It is shown, what, in Mendeleev's opinion, is the connection between philosophy and science, how important the problem was for him.
A. A. Ivanova
doaj  

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

open access: yesFEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

Positivist ideas in the philosophical legacy of Ivan Franko: An epistemological dimension

open access: yesГуманітарні студії: педагогіка, психологія, філософія
The research relevance is determined by the need to redefine the epistemological foundations of the Ukrainian philosophical tradition of the late 19th – early 20th centuries through the prism of the reception of positivist ideas in the works of Ivan ...
S. Suprun
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

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