Results 41 to 50 of about 168,933,403 (296)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Learning and knowing as semiosis: Extending the conceptual apparatus of semiotics
Sign Systems Studies, 2019 If all knowing comes from semiosis, more concepts should be added to the semiotic toolbox. However, semiotic concepts must be defined via other semiotic concepts. We observe an opportunity to advance the state-of-the-art in semiotics by defining concepts
Cary Campbell, Alin Olteanu, Kalevi Kull
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Čtyři empirické principy Ehrenfrieda Walthera von Tschirnhause
Filosofický časopis, 2022 This historically oriented study is dedicated to the German naturalist, mathematician and philosopher Ehrenfried Walther von Tschirnhaus (1651–1708) and aims to introduce his main philosophical-logical work, Medicina mentis. After a biographical overview,
Vrtílka, Pavel
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Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
The moral self, moral knowledge and God: an analysis of the theory of Samuel Clarke [PDF]
, 1984 The principal aim of this work is to ascertain a clear understanding of Clarke's moral theory, one which has suffered from neglect and misunderstanding. The assumption that his 'rational intuitionism' is given little if any epistemological grounding, is ...
Ducharme, Howard M, Ducharme, Howard M.
core +1 more source
ON THE CREATION OF A RESEARCH COMPETENCIES DEVELOPMENT MODEL FOR HIGHER EDUCATION PROGRAMS GRADUATES
Высшее образование в России, 2018 The article addresses one of the most urgent issues of the development of higher education in the light of the challenges of the strategy of scientific and technological development of the Russian Federation and the National system of qualifications ...
E. V. Karavaeva +2 more
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Understanding knowledge sharing in an organization: a perspective of actor-network theory
, 2017 This paper set out to propose the actor-network theory (ANT) as a lens through which to understand and interpret the sociotechnical knowledge sharing challenges in organisations. The methodology for this study was developed within the context of ANT by
Lee-Anne Harker +4 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Teoria cunoștinței: Angajamentele epistemologice tacite ale lui Nicolae Bagdasar
Studii de Istorie a Filosofiei Româneşti, 2021 Through the filter of his specific two steps method in approaching theories of knowledge, Bagdasar seems to invite his interpreter to consider solely the systematic level.
Marius Augustin Drăghici
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