Results 41 to 50 of about 673,908 (257)

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier   +11 more
wiley   +1 more source

ON THE CREATION OF A RESEARCH COMPETENCIES DEVELOPMENT MODEL FOR HIGHER EDUCATION PROGRAMS GRADUATES

open access: yesВысшее образование в России, 2018
The article addresses one of the most urgent issues of the development of higher education in the light of the challenges of the strategy of scientific and technological development of the Russian Federation and the National system of qualifications ...
E. V. Karavaeva   +2 more
doaj  

Reassessing Bone Marrow Aspirate and Trephine Biopsies in Staging for Paediatric and Young Adult Patients With Ewing Sarcoma and Rhabdomyosarcoma

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Ewing sarcoma (ES) and rhabdomyosarcoma (RMS) are aggressive malignancies in children and adolescents where metastases impact prognosis. 18F‐fluoro‐2‐deoxy‐d‐glucose positron emission tomography/computed tomography (FDG‐PET/CT) and bone marrow aspirate and trephine biopsies (BMAT) are used to identify disease involvement.
Imogen Andrews   +3 more
wiley   +1 more source

MOLYNEUX'S QUESTION AS ONE OF THE PROBLEMS OF THEORY OF PERCEPTION

open access: yesДискурс, 2018
The paper contains analysis of Molyneux's question, one of the greatest problems of theory of perception. The problem can be put as, “Could a man born blind and once given the ability to see recognize how things known to him by touch look like?” The ...
A. I. Ponomarev
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo   +5 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

About some aspects of D.I. Mendeleev's world-outlook

open access: yesТонкие химические технологии, 2009
In this paper, the section «World outlook» of D.I. Mendeleev's book «Cherished Thoughts» is analyzed. It is shown, what, in Mendeleev's opinion, is the connection between philosophy and science, how important the problem was for him.
A. A. Ivanova
doaj  

Le sens de l’être. Heidegger et le néokantisme

open access: yesMethodos, 2004
It is argued, that Neokantianism – often criticized polemically by Heidegger and his followers –, especially the Neokantianism of his teacher Heinrich Rickert, presents a more thorough theory concerning the fundaments of human understanding than ...
Christian Krijnen
doaj   +1 more source

Scrutinizing the Smart City Index: a multivariate statistical approach [PDF]

open access: yesZbornik radova Ekonomskog fakulteta u Rijeci : časopis za ekonomsku teoriju i praksu, 2019
The smart city represents a frequently elaborated concept which however comes short in delivering a consistent definition. Nevertheless, almost every description has always been oriented to its technological component, sustainable ...
Olga Bogdanov   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

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