Results 81 to 90 of about 5,894,286 (375)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
From Platonic anamnesis to the architectonics of philosophical knowledge: The historical-philosophical status of reminiscence [PDF]
Известия Саратовского университета. Новая серия: Серия Философия. Психология. ПедагогикаIntroduction. The article explores the phenomenon of reminiscence as a possible method of constructing the history of philosophy, which transforms the Platonic concept of recollection (anamnesis) into a tool for synthesizing universal ideas and ...
Romaschenko, Maria A. +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
The (non)Theory of the Knowledge Firm [PDF]
This paper argues that the mainstream approaches to the theory of the firm do not provide a theory of the human capital based or knowledge based firm. We examine the textbook (neoclassical) theory of the firm, the transaction cost model, the incentive ...
Paul Walker
core
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
The utility of knowledge in inductive learning [PDF]
, 1990 In this paper, we demonstrate how different forms of background knowledge can be integrated with an inductive method for generating constant-free Horn clause rules. Furthermore, we evaluate, both theoretically and empirically, the effect that these types
Kibler, Dennis Kibler +1 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Studii de Istorie a Filosofiei Româneşti, 2021 In Teoria cunoștinței (Theory of knowledge), the author N. Bagdasar enunciated the following idea: the metaphysics is conditioned by the theory of knowledge, since the first is a knowledge placed from the beginning under rules.
Viorel Cernica
doaj
How Does Leader Empowering Behavior Promote Employee Knowledge Sharing? The Perspective of Self-Determination Theory [PDF]
, 2021 Shuting Xiang +4 more
openalex +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source