Results 81 to 90 of about 991,191 (336)

Wikipedia and theories of knowledge in encyclopaedism [PDF]

open access: yes, 2019
Algunas tecnologías parecen cambiar de manera inevitable las sociedades en las que son usadas. Las tecnologías de la información hacen esto de forma muy interesante. La imprenta es una de estas tecnologías. Al difundirse por Europa el uso de la imprenta la facilidad y utilidad de la lectura creció de tal manera que empezaron a surgir problemas.
David Robert, Hastings Ruiz
openaire   +2 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Ce este și cum poate fi cunoscut datul. Comentariu pe marginea capitolului despre pozitivism din Teoria cunoștinței

open access: yesStudii de Istorie a Filosofiei Româneşti, 2021
In Teoria cunoștinței (Theory of knowledge), the author N. Bagda­sar enunciated the following idea: the metaphysics is conditioned by the theory of knowledge, since the first is a knowledge placed from the beginning under rules.
Viorel Cernica
doaj  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Data‐driven performance metrics for neural network learning

open access: yesInternational Journal of Adaptive Control and Signal Processing, EarlyView., 2023
Summary Effectiveness of data‐driven neural learning in terms of both local mimima trapping and convergence rate is addressed. Such issues are investigated in a case study involving the training of one‐hidden‐layer feedforward neural networks with the extended Kalman filter, which reduces the search for the optimal network parameters to a state ...
Angelo Alessandri   +2 more
wiley   +1 more source

Knowledge, strategy, and the theory of the firm [PDF]

open access: yesStrategic Management Journal, 1996
AbstractThis paper argues that firms have particular institutional capabilities that allow them to protect knowledge from expropriation and imitation more effectively than market contracting. I argue that it is these generalized institutional capabilities that allow firms to generate and protect the unique resources and capabilities that are central to
openaire   +3 more sources

The Scientific Research and the Problem of its Justification [PDF]

open access: yesIdeas y Valores, 2005
The purpose of this article is to show the conflict that has to do with epistemic and methodological issues involved in Boyle/Spinoza discussion, which allows to appreciate how it should be reassessed, at least two things, in the growing natural science ...
José Luis Cárdenas
doaj  

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