Results 101 to 110 of about 1,076,493 (308)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The Diaries of Fănuș Neagu [PDF]

Diversitate si Identitate Culturala in Europa
In his final years, starting from 2002, Fănuș Neagu introspected on his existence through journal entries. Published in 2004 by Editura Semne in Bucharest (225 pages, 12 x 17 cm format), Jurnal cu fața ascunsă encompasses the writer’s comments from 10 ...
Lucian CHIȘU
doaj  

Semiotics and structuralism [Introduction to theory of Literature]

, 2011
Educação Superior::Linguística, Letras e Artes::LetrasPresents a class of Professor Paul Fry that explores the work of Ferdinand de Saussure and through it he explains the semiotics movement.
Fry, Paul H.
core  

Material objects and psychological theory: A conceptual literature review

, 2015
Background: This review offers a conceptual summary and critique of psychological theories and research concerning the use of material objects and their possible role in clinical work.
Thomson, L., Solway, R., Camic, P., Chatterjee, H.   +3 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Semiotics and structuralism [Introduction to theory of Literature]

, 2016
Presents a class of Professor Paul Fry that explores the work of Ferdinand de Saussure and through it he explains the semiotics movement. He also approaches the concepts of langue and parole, signifier and signified, and synchrony and diachrony.
Fry, Paul H.
core  

Does Egyptology Need a “Theory of Literature”?

, 1996
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openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The postmodern psyche [Introduction to theory of Literature]

, 2016
Presents a class of Professor Paul H. Fry that evaluates the works of Gilles Deleuze, Felix Guattari and Slavoj Zizek to talk about post-modern psyche. Postmodernism is shown through visual arts, theater, music, painting and architecture.
Fry, Paul H.
core