Results 81 to 90 of about 5,503,578 (287)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Horava-Lifshitz gravity: a status report
, 2011 This is intended to be a brief introduction and overview of Horava-Lifshitz gravity. The motivation and all of the various version of the theory (to date) are presented.
Blas D +20 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Risk Management and Healthcare PolicyChunyun Tan,1 Jiangwei Hu,1 Hongxuan Tong,2 Jiale Zhang2,3 1School of Chinese Literature and Media, Hubei University of Arts and Science, Xiangyang, Hubei, People’s Republic of China; 2Institute of Basic Theory for Chinese Medicine, China Academy of ...
Tan C, Hu J, Tong H, Zhang J
doaj
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
, 1979 As an imaginative writer Sartre is fascinated by the role of imagination in the creative process. Moreover his critical, psychological and philosophical writings witness to a constant meditation on the function and status of the imaginary. This book, originally published in paperback in 1979 under the ISBN 978-0-900547-57-7, was made Open Access in ...
openaire +3 more sources
"International Trade Theory and Policy: A Review of the Literature" [PDF]
This paper provides a survey of the literature on trade theory, from the classical example of comparative advantage to the New Trade theories currently used by many advanced countries to direct industrial policy and trade.
Sunanda Sen
core
Deformed supersymmetric gauge theories from the fluxtrap background
, 2013 The fluxtrap background of string theory provides a transparent and algorithmic way of constructing supersymmetric gauge theories with both mass and Omega-type deformations in various dimensions.
Orlando, Domenico, Reffert, Susanne
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source