Results 71 to 80 of about 1,076,493 (308)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
The social permeability of reader and text [Introduction to theory of Literature]
, 2016 Presents a lecture of Professor Paul H. Fry that compares the theories of literary history exposed by Mikhail Bakhtin and Hans Robert Jauss. The vision of literature and history of Foucault and Barthes and the formalist theory are discussed by the ...
Fry, Paul H.
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The American Literature Scholar in the Digital Age
, 2010 Essays reflecting on the development of the first wave of digital American literature ...
Jewell, Andrew, Earhart, Amy
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
"The ghost within the ghost in the machine": an interview with Jerome McGann
MatLit, 2016 Focusing mostly on McGann’s recent work, this interview addresses the reasons underlying his critical moves, and looks at his scholarly poetics of interpretation as a material engagement with imaginative works.
Brito, Matheus de, Portela, Manuel
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
“The Gray House” by Mariam Petrosyan in the context of the literary tradition of magical realism
RUDN Journal of Studies in Literature and Journalism, 2019 The paper deals with a comprehensive analysis of the formal and substantive components of Mariam Petrosyan’s novel “The Gray House” (“The House in Which ...”). The publication of the novel in 2009 provoked extremely diverse criticism.
Vladimir A. Meskin, Lada V. Gaidash
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source