Results 91 to 100 of about 570,392 (307)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Study of exclusive breastfeeding behaviour based on the theory of planned behaviour in pregnant women in Isfahan in 2021

Family Medicine & Primary Care Review, 2023
GHAZAL KHANJARI, MAJID RAHIMI, NARGES KALANTARI, SHAGHAYEGH AFSHAR, AZARDOKHT CHAHARLANG, FARAHNAZ DEHGHANI, MAHBOOBEH AMINI, MOHAMMAD JAVAD TARRAHI   +7 more
doaj   +1 more source

Adopting Organic Agriculture: An Investigation Using the Theory of Planned Behaviour [PDF]

Certified organic production by small-scale farmers in developing countries is increasingly promoted as an opportunity to access a growing and dynamic market, while at the same time, enhance productivity and improve incomes.
Hattam, Caroline
core   +1 more source

Predicting breastfeeding in women living in areas of economic hardship : explanatory role of the theory of planned behaviour [PDF]

, 2008
This study employed the theory of planned behaviour (TPB) and additional variables (descriptive norm, moral norm, self-identity) to investigate the factors underlying breastfeeding intention and subsequent breastfeeding at four time points (during ...
Bharj, Kuldip, Clarke, Graham, Conner, Mark, Dyson, Lisa, Green, Josephine, McMillan, Brian, Renfrew, Mary, Woolridge, Mike   +7 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Understanding Teachers’ Intention and Behaviour Towards Inclusive Education in Ghana: Applying the Theory of Planned Behaviour

Education Sciences
United Nations Sustainable Development Goal 4 advocates for equitable access to and participation in quality inclusive education for all learners. Inclusive education has gained worldwide recognition for promoting equity and social justice for students ...
Michael Amponteng, Danielle Tracey, William Nketsia   +2 more
doaj   +1 more source

Cognitive representations of disability behaviours in people with mobility limitations : consistency with theoretical constructs [PDF]

, 2008
Disability is conceptualised as behaviour by psychological theory and as a result of bodily impairment by medical models. However, how people with disabilities conceptualise those disabilities is unclear.
Bandura A, Bandura A, Bellamy N, Diane Dixon, Ewart C K, Fransella F, Johnston M, Johnston M, Kelly G A, Leventhal H, Marie Johnston, Martin J, Patrick D L, Pollard B, Toshima M T, Ware J E, World Health Organization, World Health Organization   +17 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Social factors influencing waste separation behaviour among the multi-class residents in a megacity: A Survey analysis from a community in Bangkok, Thailand

Sustainable Futures
Effective waste separation at the source is vital for sustainable waste management globally. However, motivating people to participate in waste separation can be challenging, especially in developing countries' megacities, where rapid urbanization and ...
Unruan Leknoi, Annop Yiengthaisong, Suched Likitlersuang   +2 more
doaj   +1 more source

Applying an extended theory of planned behaviour to predict breakfast consumption in adolescents [PDF]

, 2016
BACKGROUND/OBJECTIVES: Breakfast skipping increases during adolescence and is associated with lower levels of physical activity and weight gain. Theory-based interventions promoting breakfast consumption in adolescents report mixed findings, potentially ...
A Grønhøj, A Hoyland, A Rivis, AM Hewitt, AM Siega-Riz, AO Odegaard, B Mullan, BA Mullan, BA Mullan, C Berg, C Kennedy, C Vereecken, CJ Armitage, CL Wong, CS Berkey, CS DeJong, D Neumark-Sztainer, E L Davies, EJ Kothe, FF Sniehotta, G Haddock, GC Rampersaud, GF Moore, GF Moore, GR Sandercock, I Ajzen, I Ajzen, J Ogden, J Utter, K Chan, K Kowalski, K Tapper, K Van der Horst, L Gummeson, L Hallstrom, L Ryan, M Conner, M E Clegg, MJ Duncan, MK Martens, MT Timlin, N Pearson, N Unusan, RRC McEachan, S Kennedy, S Michie, S Murphy, SK Riebl, TJ Cole, Z Gharlipour, Z Hosseini   +50 more
core   +3 more sources