Results 31 to 40 of about 427,138 (218)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Breakdown of field theory in near-horizon regions
Journal of High Energy PhysicsWe discuss back-reaction in the semiclassical treatment of quantum fields near a black hole. When the state deviates significantly from Hartle-Hawking, simple energetic considerations of back-reaction give rise to a characteristic radial distance scale ∼
Tom Banks +2 more
doaj +1 more source
Modular parallel transport of multiple intervals in 1+1-dimensional free fermion theory
Journal of High Energy Physics, 2023 Modular parallel transport is a generalization of Berry phases, applied to modular (entanglement) Hamiltonians. Here we initiate the study of modular parallel transport for disjoint field theory regions.
Bowen Chen +3 more
doaj +1 more source
A Dual Mind Approach to Understanding the Conscious Self and Its Treatment
NeuroSci, 2021 In this paper I will address questions about will, agency, choice, consciousness, relevant brain regions, impacts of disorders, and their therapeutics, and I will do this by referring to my theory, Dual-brain Psychology, which posits that within most of ...
Fredric Schiffer
doaj +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Metropolen-orientierte Politik und territoriale Kohäsion — Notwendigkeit oder Widerspruch?
Raumforschung und Raumordnung, 2008 Regularly, new concepts on how the territory should develop arise in spatial planning politics. Previous ideas include: active or passive restructuring, functionally balanced territories or interregional specialization, target for balance or growth ...
Patrick Küpper
doaj +1 more source
Journal of Chemistry, 2022 This work aims to study the extent of the association between the numbers of COVID-19 infections among the regions of Saudi Arabia using a graph theory, especially the calculation of the minimum spanning tree.
Samirah H. Alsulami, Jalal H. Bayati
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source