Results 51 to 60 of about 174,044,778 (302)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Journal of Chemistry, 2022 This work aims to study the extent of the association between the numbers of COVID-19 infections among the regions of Saudi Arabia using a graph theory, especially the calculation of the minimum spanning tree.
Samirah H. Alsulami, Jalal H. Bayati
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Theory and Practice of the Public Sector Savings: The Case of Czech Regions
Transylvanian Review of Administrative Sciences, 2014 In recent years, the necessity to allocate resources in economically rational ways has been amplified in the context of budget austerity measures and the overall tendency for balanced public budgets.
Milan PŮČEK, František OCHRANA
doaj +2 more sources
Socio-Economic Status of Russia’s Median Region
Пространственная экономика, 2005 Theoretical conclusions have been made as to the character and key features of a region’s «median position» and their influence on the main objectives and tendencies in managing the development of such regions.
Alexander Ivanovich Tatarkin
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Are all beliefs equal? Implicit belief attributions recruiting core brain regions of theory of mind.
PLoS ONE, 2014 Humans possess efficient mechanisms to behave adaptively in social contexts. They ascribe goals and beliefs to others and use these for behavioural predictions. Researchers argued for two separate mental attribution systems: an implicit and automatic one
Agnes Melinda Kovács +4 more
doaj +1 more source
Grasas y Aceites, 1994 The authentication of extra virgin olive oils from different regions of Spain, Italy and Portugal, by means of their fatty acids, alcohols, sterols, methyl sterols and hydrocarbons content, has been investigated.
R. Aparicio, V. Alonso, M. T. Morales
doaj +1 more source
Action processing and mirror neuron function in patients with amyotrophic lateral sclerosis: an fMRI study. [PDF]
PLoS ONE, 2015 Amyotrophic lateral sclerosis (ALS) is a highly debilitating and rapidly fatal neurodegenerative disease. It has been suggested that social cognition may be affected, such as impairment in theory of mind (ToM) ability. Despite these findings, research in
Laura Jelsone-Swain +3 more
doaj +1 more source