Results 61 to 70 of about 2,758,604 (298)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Metropolen-orientierte Politik und territoriale Kohäsion — Notwendigkeit oder Widerspruch?

Raumforschung und Raumordnung, 2008
Regularly, new concepts on how the territory should develop arise in spatial planning politics. Previous ideas include: active or passive restructuring, functionally balanced territories or interregional specialization, target for balance or growth ...
Patrick Küpper
doaj   +1 more source

COVID-19 Infection Structure Analysis Based on Minimum Spanning Tree Visualization in the Kingdom of Saudi Arabia Regions

Journal of Chemistry, 2022
This work aims to study the extent of the association between the numbers of COVID-19 infections among the regions of Saudi Arabia using a graph theory, especially the calculation of the minimum spanning tree.
Samirah H. Alsulami, Jalal H. Bayati
doaj   +1 more source

The region of validity of homogeneous nucleation theory [PDF]

Physics Letters B, 1999
8 pages, 4 figures.
STRUMIA, ALESSANDRO, Tetradis N, Wetterich C.   +2 more
openaire   +3 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Sex differences in the influence of body mass index on anatomical architecture of brain networks. [PDF]

, 2017
Background/objectivesThe brain has a central role in regulating ingestive behavior in obesity. Analogous to addiction behaviors, an imbalance in the processing of rewarding and salient stimuli results in maladaptive eating behaviors that override ...
Alaverdyan, M, Ashe-McNalley, C, Bhatt, R, Fling, C, Gupta, A, Hamadani, K, Labus, JS, Mayer, EA, Naliboff, B, Sanmiguel, CP, Tillisch, K, Torgerson, C, Van Horn, JD   +12 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Detailed and exhaustive study of the authentication of European virgin olive oils by SEXIA expert system

Grasas y Aceites, 1994
The authentication of extra virgin olive oils from different regions of Spain, Italy and Portugal, by means of their fatty acids, alcohols, sterols, methyl sterols and hydrocarbons content, has been investigated.
R. Aparicio, V. Alonso, M. T. Morales
doaj   +1 more source

Action processing and mirror neuron function in patients with amyotrophic lateral sclerosis: an fMRI study. [PDF]

PLoS ONE, 2015
Amyotrophic lateral sclerosis (ALS) is a highly debilitating and rapidly fatal neurodegenerative disease. It has been suggested that social cognition may be affected, such as impairment in theory of mind (ToM) ability. Despite these findings, research in
Laura Jelsone-Swain, Carol Persad, David Burkard, Robert C Welsh   +3 more
doaj   +1 more source