Results 91 to 100 of about 2,791,202 (312)

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

open access: yesMolecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad   +13 more
wiley   +1 more source

Concepts of relative velocity [PDF]

open access: yesarXiv, 2011
The central concept of the theory of relativity is the relativity of velocity. The velocity of a material body is not an intrinsic property of the body; it depends on a free choice of reference system. Relative velocity is thus reference-dependent, it is not an absolute concept. We stress that even zero-velocity must be relative. Every reference system
arxiv  

La aplicación física de la geometría astral como confirmación de la teoría kantiana del conocimiento

open access: yesLogos, 2007
The appearance of the non-Euclidean or astral geometries seemed to contradict the philosophy of the Kant´s mathematics. He had considered the possibility of a supreme geometry, but he discarded it due to it was not synthetically related with the ...
Juan Cano de Pablo
doaj  

Inextendibilty of the Maximal Global Hyperbolic Development in Electrogowdy spacetimes

open access: yesEPJ Web of Conferences, 2013
The problem of determinism in General Relativity appears even if one assumes that the spacetime is globally hyperbolic, i.e. that it contains a hypersurface that is intersected by any causal curve exactly once.
Nungesser Ernesto
doaj   +1 more source

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu   +7 more
wiley   +1 more source

Relativity of simultaneity in secondary school: an analysis based on the Theory of the Conceptual Fields

open access: yesJournal of Physics: Conference Series, 2018
In this paper, we present results about the conceptualization of the relativity of simultaneity and the operational invariants used by high school students. The Theory of Conceptual Fields is adopted to design, analyse and evaluate a didactic sequence to
María Rita Otero   +2 more
semanticscholar   +1 more source

Four paradoxes about the special theory of relativity [PDF]

open access: yesarXiv, 2016
Various paradoxes about the relativity theory have been developed since the birth of this theory. Each paradox somewhat shows people's query about the relativity theory, and solving of each paradox demonstrates the correctness of relativity theory once again.
arxiv  

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

open access: yesMolecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy   +12 more
wiley   +1 more source

The probability that random positive integers are k-wise relatively prime [PDF]

open access: yesInt. J. Number Theory 9 (2013) 1263-1271, 2012
An s-tuple of positive integers are k-wise relatively prime if any k of them are relatively prime. Exact formula is obtained for the probability that s positive integers are k-wise relatively prime.
arxiv  

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

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