Results 101 to 110 of about 166,198,655 (304)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Being, Becoming and the Undivided Universe: A Dialogue between Relational Blockworld and the Implicate Order Concerning the Unification of Relativity and Quantum Theory [PDF]
, 2011 In this paper two different approaches to unification will be compared, Relational Blockworld (RBW) and Hiley's implicate order. Both approaches are monistic in that they attempt to derive matter and spacetime geometry `at once' in an interdependent ...
Silberstein, Michael
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Relativity as Support for Presentism: A Modest Evidential Argument [PDF]
, 2013 Presentism is roughly the view that only the present exists. This view requires an absolute simultaneity relation. The special theory of relativity, however, is highly successful and does not account for absolute simultaneity.
Nasmith, Benjamin B
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
In the hyperbolic theory of special relativity is space also hyperbolic?
In the hyperbolic theory of special relativity the space of velocities, the kinematic space, is hyperbolic of radius of negative curvature c the velocity of light. Space itself could be either Euclidean or hyperbolic.
Barrett, John F.
core +1 more source
Philosophical, Physical and Media Electron [PDF]
In Medias Res, 2019 In the contemporary age of everincreasing influence of electronic media as much as on an individual psyche as on the society as a whole, it would be of great value to undertake a detailed analysis of the very foundation of that means of communication ...
Marko Grba
doaj
Universe, 2019 The ‘projective theory of relativity’ is a theory developed historically by Oswald Veblen and Banesh Hoffmann, Jan Arnoldus Schouten and David van Dantzig.
Jacques L. Rubin
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
La aplicación física de la geometría astral como confirmación de la teoría kantiana del conocimiento
Logos, 2007 The appearance of the non-Euclidean or astral geometries seemed to contradict the philosophy of the Kant´s mathematics. He had considered the possibility of a supreme geometry, but he discarded it due to it was not synthetically related with the ...
Juan Cano de Pablo
doaj