Results 111 to 120 of about 166,198,655 (304)
The Extended Theory of Relativity
This paper combines Albert Einstein's General Theory of Relativity(in which he proposes space-time) and the second law of Thermodynamics(entropy) to propose a new cause for cosmic expansion and to provide justification for a possible beginning and end of the universe.
openaire +2 more sources
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
How Hume and Mach Helped Einstein Find Special Relativity [PDF]
, 2004 In recounting his discovery of special relativity, Einstein recalled a debt to the philosophical writings of Hume and Mach. I review the path Einstein took to special relativity and urge that, at a critical juncture, he was aided decisively not by any ...
John D. Norton +2 more
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Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Some Thoughts on Relativity and the Flow of Time: Einstein's Equations given Absolute Simultaneity [PDF]
, 2004 The A-theory of time has intuitive and metaphysical appeal, but suffers from tension, if not inconsistency, with the special and general theories of relativity (STR and GTR).
Pitts, J. Brian
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
On the formal statement of the special principle of relativity [PDF]
, 2011 The aim of the paper is to develop a proper mathematical formalism which can help to clarify the necessary conceptual plugins to the special principle of relativity and leads to a deeper understanding of the principle in its widest ...
Gomori, Marton, Szabo, Laszlo E.
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Michelson, FitzGerald and Lorentz: the origins of relativity revisited [PDF]
, 2003 It is argued that an unheralded moment marking the beginnings of relativity theory occurred in 1889, when G. F. FitzGerald, no doubt with the puzzling 1887 Michelson-Morley experiment fresh in mind, wrote to Heaviside about the possible effects of motion
Harvey R Brown, Brown, Harvey R.
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source