Results 111 to 120 of about 173,551,104 (305)
Death, Time, and the Theory of Relativity [PDF]
Journal of Pain and Symptom Management, 2011 Abstract This chapter contains a reprint of “Death, Time, and the Theory of Relativity,” which was published in 2011 in the Journal of Pain and Symptom Management. The author addresses the question of what providing end-of-life care is worth, and how this can be justified using some basic economic and quality-of-life metrics.
openaire +2 more sources
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Eclipse to Confirm the General Theory of Relativity [PDF]
, 2015 One of the milestones of the science of light commemorated during this International Year of Light and Light-based Technologies is “the embedding of light in cosmology through general relativity in 1915,” that is, the celebration of the centenary of ...
Beléndez, Augusto
core
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Universe, 2019 The ‘projective theory of relativity’ is a theory developed historically by Oswald Veblen and Banesh Hoffmann, Jan Arnoldus Schouten and David van Dantzig.
Jacques L. Rubin
doaj +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
La aplicación física de la geometría astral como confirmación de la teoría kantiana del conocimiento
Logos, 2007 The appearance of the non-Euclidean or astral geometries seemed to contradict the philosophy of the Kant´s mathematics. He had considered the possibility of a supreme geometry, but he discarded it due to it was not synthetically related with the ...
Juan Cano de Pablo
doaj
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Special Theory of Relativity and the Lorentz Force [PDF]
, 2003 Efforts to demonstrate that the application of Lorentz transformations leads to the form Y' = [Y - (v/c)N] (at least to the leading orders of approximation), which has been elevated to the criterion for the validity of STR , has been the main point in ...
Noninski, Vesselin
core
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source