Results 151 to 160 of about 166,198,655 (304)

What can we Learn about the Ontology of Space and Time from the Theory of Relativity [PDF]

open access: yes, 2012
This chapter presents an opinionated assessment of what we can learn about the ontology of space and time from the special and general theories of relativity.
Norton, John D.
core  

An Extreme Rotating Black Hole in New Massive Gravity Theory

open access: yesRevista Politécnica, 2017
New Massive Gravity is an alternative theory to General Relativity that is used to describe the gravitational field in a (2+1)-dimensional spacetime. Black hole solutions have been found in this theory, in particular an asymptotically anti-de Sitter ...
Mario Llerena   +2 more
doaj  

More on General Theory of Relativity vs. Special Theory of Relativity, Absolute Theory of Relativity, Parameterized Special Theory of Relativity, and NonInertial MultiRelativity

open access: yesHyperSoft Set Methods in Engineering
This paper continues and completes the analyses from paper [1]. The distinction between Special Relativity (SR) and General Relativity (GR) essentially boils down to whether gravity and acceleration are included in the math calculation. Also, distinctions between General Theory of Relativity vs.
openaire   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Coordinates, observables and symmetry in relativity [PDF]

open access: yes, 2007
We investigate the interplay and connections between symmetry properties of equations, the interpretation of coordinates, the construction of observables, and the existence of physical relativity principles in spacetime theories. Using the refined notion
Westman, Hans   +3 more
core  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Refreshing the Theory of Relativity

open access: yes
The theory of relativity must be reworked. Quite simply because it does not properly address the question of time. It avoids confronting it, taking its object for granted, hidden as it is in punctual clocks that don't exist. However, it's not a question of getting rid of it, nor fundamentally modifying its mathematical formalism.
openaire   +2 more sources

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