Results 141 to 150 of about 10,930 (306)

Spacetime Emergence: An (In)effective Story

open access: yesPhilosophy of Physics
Physicists and philosophers are increasingly prone to regarding our current physical theories as providing ‘effective descriptions’ of real-world systems.
Mike D. Schneider
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Gravitational radiation of a spherically symmetric source in f(R)-gravitation

open access: yesEuropean Physical Journal C: Particles and Fields
It is shown that Birkhoff’s theorem for the general theory of relativity is overcome in the f(R)-theory of gravitation. That means, the f(R)-theory of gravitation, unlike Einstein’s general theory of relativity, does not forbid gravitational radiation ...
Pham Van Ky   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

The Place of the Theory of Relativity in the Area of Human Knowledge

open access: yes, 2006
The paper has outlined a broad perspective of references for the (particular and general) theory of relativity to various domains of human knowledge and to technique. These references are presented both in their current and historical dimension.
Such, Jan
core  

Lo spazio-tempo nei viaggi medievali nell'aldilà

open access: yesÉtudes romanes de Brno, 2009
Medieval descriptions of journeys to the Other World often contain a temporal distortion which their protagonists experience personally; the movement in the space lead them to cross a temporal border also, so that their return to the earthly space does ...
Massimo Bonafin
doaj  

Theory of Relativity [PDF]

open access: yesJ Gen Intern Med, 2013
Becker D.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

An Extreme Rotating Black Hole in New Massive Gravity Theory

open access: yesRevista Politécnica, 2017
New Massive Gravity is an alternative theory to General Relativity that is used to describe the gravitational field in a (2+1)-dimensional spacetime. Black hole solutions have been found in this theory, in particular an asymptotically anti-de Sitter ...
Mario Llerena   +2 more
doaj  

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