Results 91 to 100 of about 168,624,924 (258)
Expressive CP-ABE Scheme for Mobile Devices in IoT Satisfying Constant-Size Keys and Ciphertexts
IEEE Access, 2017 Designing lightweight security protocols for cloud-based Internet-of-Things (IoT) applications for battery-limited mobile devices, such as smart phones and laptops, is a topic of recent focus.
Vanga Odelu +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Using autonomous components to improve runtime qualities of software
, 2011 In the development of software systems, quality properties should be considered along with the development process so that the qualities of software systems can be inferred and predicted at the specification and design stages and be evaluated and ...
Jiao, W., W. Jiao
core +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Towards a Behavioral Software Engineering [PDF]
, 2014 Throughout the history of Software Engineering (SE) it has been repeatedly found that the humans involved, i.e. the engineers and developers in addition to other stakeholders, are a key factor in determining project outcomes and success.
Lars-Göran Wallgren +9 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Accuracy Test of Software Architecture Compliance Checking Tools – Test Instruction [PDF]
, 2015 Software Architecture Compliance Checking (SACC) is an approach to verify conformance of implemented program code to high-level models of architectural design.
Brinkkemper., Sjaak +4 more
core
Summary of the First Workshop on Sustainable Software for Science: Practice and Experiences (WSSSPE1) [PDF]
, 2014 Challenges related to development, deployment, and maintenance of reusable software for science are becoming a growing concern. Many scientists’ research increasingly depends on the quality and availability of software upon which their works are built ...
Ketan Maheshwari +35 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source