Results 81 to 90 of about 168,624,924 (258)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Theory and application of digital control proceedings of the IFAC Symposium, New Delhi, India, 5-7 January 1982

, 1982
Theory and Application of Digital Control contains the proceedings of the IFAC Symposium held at New Delhi, India on January 5-7, 1982. This book particularly presents the texts of the five plenary talks and the 110 papers of the symposium.
International Federation of Automatic Control, IFAC Symposium on Theory and Application of Digital Control <1982, New Delhi, India>, Mahalanabis, A. K.   +2 more
core  

The Software Invention Cube: A classification scheme for software inventions [PDF]

, 2008
The patent system protects inventions. The requirement that a software invention should make ‘a technical contribution’ turns out to be untenable in practice and this raises the question, what constitutes an invention in the realm of software.
Bergstra, J.A., Klint, P., Klint, Paul, Bergstra, J.A. (Jan), Bergstra, Jan, Bergstra, Jan A, Klint, P. (Paul)   +6 more
core  

A systematic literature review on the industrial use of software process simulation [PDF]

, 2014
Context Software process simulation modelling (SPSM) captures the dynamic behaviour and uncertainty in the software process. Existing literature has conflicting claims about its practical usefulness: SPSM is useful and has an industrial impact ...
Petersen, Kai,, Wohlin, Claes, Petersen, Kai, Wohlin, Claes,, bin Ali, Nauman, bin Ali, Nauman,, Ali, Nauman   +6 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Agile Development of Safety-Critical Software [PDF]

, 2011
Agile software development has gained an enormous success in all kinds of product and system development. It has been expected to provide more control for the development process and to be able to deliver value to customers and developers earlier and to ...
Vuori, Matti
core  

Semantic Segmentation of SLAR Imagery with Convolutional LSTM Selectional AutoEncoders

Remote Sensing, 2019
We present a method to detect maritime oil spills from Side-Looking Airborne Radar (SLAR) sensors mounted on aircraft in order to enable a quick response of emergency services when an oil spill occurs.
Antonio-Javier Gallego, Pablo Gil, Antonio Pertusa, Robert B. Fisher   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Software energy profiling: comparing releases of a software product [PDF]

, 2016
In the quest for energy efficiency of Information and Communication Technology, so far research has mostly focused on the role of hardware. However, as hardware technology becomes more sophisticated, the role of software becomes crucial.
Lago, Patricia, Jan Martijn van der Werf, Brinkkemper, Sjaak, Patricia Lago, Lago, P.; id_orcid, Jagroep, Erik, Rob van Vliet, Procaccianti, G.; id_orcid, Blom, Leen, Procaccianti, Guiseppe, Sub Algemeen Software Systems, Sub Software Production, Brinkkemper, S., Erik A. Jagroep, Leen Blom, Software Production, Blom, L., Giuseppe Procaccianti, van Vliet, Rob, Sjaak Brinkkemper, Jagroep, E.A., van der Werf, J.M.E.M.   +21 more
core   +2 more sources