Results 71 to 80 of about 504,509 (264)
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
The Influence of Mexican Hat Recurrent Connectivity on Noise Correlations and Stimulus Encoding
Frontiers in Computational Neuroscience, 2017 Noise correlations are a common feature of neural responses and have been observed in many cortical areas across different species. These correlations can influence information processing by enhancing or diminishing the quality of the neural code, but ...
Robert Meyer +6 more
doaj +1 more source
A theory of data-intensive software services [PDF]
Service Oriented Computing and Applications, 2009 We introduce Abstract State Services (AS2s) as an abstraction of data-intensive services that can be made available for use by other systems, e.g. via the web. An AS2 combines a hidden database layer with an operation-equipped view layer, and can be anything from a simple function to a full-fledged Web Information System or a Data Warehouse.
Hui Ma 0001 +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Software Process in Practice: A Grounded Theory of the Irish Software Industry [PDF]
, 2006 This paper presents the results of a Grounded Theory study of how software process and software process improvement (SPI) is applied in the practice of software development. This study described in this paper focused on what is actually happening in practice in the software industry.
Gerry Coleman, Rory O'Connor
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
HeliyonAccurately predicting freeway accident severity is crucial for accident prevention, road safety, and emergency rescue services in intelligent freeway systems.
Guanghui Wang +5 more
doaj +1 more source
Forming theories of practices for software engineering
2013 2nd SEMAT Workshop on a General Theory of Software Engineering (GTSE), 2013 The paper outlines a model for theorizing about development practices, especially taking into account the intended rationale for, actual realization of, and resulting impacts from using particular practices in varying contexts. This includes discussing of two different modes of thinking through which we can approach software development practices ...
Kari Smolander, Tero Päivärinta
openaire +3 more sources