Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
Signal Transduction and Targeted Therapy, 2022 The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer
Jiaqi Liu +8 more
semanticscholar +1 more source
Therapeutic peptides: current applications and future directions
Signal Transduction and Targeted Therapy, 2022 Peptide drug development has made great progress in the last decade thanks to new production, modification, and analytic technologies. Peptides have been produced and modified using both chemical and biological methods, together with novel design and ...
Lei Wang +8 more
semanticscholar +1 more source
Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Signal Transduction and Targeted Therapy, 2023 Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects more than 500 million population worldwide. OA was believed to be caused by the wearing and tearing of articular cartilage, but it is now more commonly ...
Q. Yao +9 more
semanticscholar +1 more source
The Evaluation of Effective Drugs for the Treatment of Non-Alcoholic Fatty Liver Disease: A Systematic Review and Network Meta-Analysis [PDF]
Advanced Pharmaceutical Bulletin, 2020 Purpose: Non-alcoholic fatty liver disease (NAFLD) and steatohepatitis are two forms of fatty liver disease with benign and malignant nature, respectively.
Ramin Jalili +6 more
doaj +1 more source
Therapeutic strategies for COVID-19: progress and lessons learned
Nature reviews. Drug discovery, 2023 Since the COVID-19 pandemic began, many potential therapeutics that target SARS-CoV-2 and/or human proteins to control viral infection have been investigated, with a few receiving authorization by regulatory agencies.
Guangdi Li +3 more
semanticscholar +1 more source
Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions
Signal Transduction and Targeted Therapy, 2023 Having a hypoxic microenvironment is a common and salient feature of most solid tumors. Hypoxia has a profound effect on the biological behavior and malignant phenotype of cancer cells, mediates the effects of cancer chemotherapy, radiotherapy, and ...
Zhou Chen +4 more
semanticscholar +1 more source
The American Journal of the Medical Sciences, 1905 n ...
Wilcox, Reynold Webb +1 more
openaire +2 more sources
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
Signal Transduction and Targeted Therapy, 2023 Microglia activation is observed in various neurodegenerative diseases. Recent advances in single-cell technologies have revealed that these reactive microglia were with high spatial and temporal heterogeneity.
Chao Gao +3 more
semanticscholar +1 more source
Endovascular treatment of carotid-cavernous fistula type A with platinium coils [PDF]
Vojnosanitetski Pregled, 2008 Background. Carotid-cavernous fistulas are abnormal communications between carotid arteries or their branches and the cavernous system caused mostly by trauma.
Ćulafić Slobodan +5 more
doaj +1 more source
Small molecule metabolites: discovery of biomarkers and therapeutic targets
Signal Transduction and Targeted Therapy, 2023 Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite signatures that have close proximity to subject’s phenotypic informative dimension,
Shi Qiu +6 more
semanticscholar +1 more source