Results 201 to 210 of about 6,381,108 (341)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Realization of a Family Systems Care Unit: A Real-Life Laboratory for Clinical Practice, Education, and Research at a Swiss University of Applied Sciences. [PDF]

J Fam Nurs
Huber E, Hilpertshauser M, Sgier C, Stark E, Fierz K, Bächi S, Fringer A, Preusse-Bleuler B.   +7 more
europepmc   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Editorial: Mesenchymal stem cells and derived extracellular vesicles as next-generation biological drugs for tissue regeneration. [PDF]

Front Pharmacol
Barbon S, Banerjee A, Porzionato A.
europepmc   +1 more source

Natural Killer Cell Immune Checkpoints and Their Therapeutic Targeting in Cancer Treatment

Anqi Lin, Peina Ye, Zhengrui Li, Aimin Jiang, Zaoqu Liu, Quan Cheng, Jian Zhang, Peng Luo   +7 more
openalex   +1 more source

Therapeutic Effects of Nano-HAp in a Rat Model of AlCl₃ Induced Neurotoxicity.

, 2019
Osama Abbas, Issa Ghada Ibrahim, Abdel-Gawad Eman Ismail   +2 more
openalex   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Editorial: Overcoming resistance in DDR inhibition: new targets and therapeutic strategies. [PDF]

Front Mol Biosci
Tsai CL, Gonçalves AC, Ahmed Z.
europepmc   +1 more source

EXPLORING BECLIN-1 THERAPEUTIC POTENTIAL IN NEURODEGENERATIVE DISEASES: FOCUS ON MULTIPLE SCLEROSIS

Arif Malik, J ISLAM, Gul Zaib, Haleema Saadia, Ayesha Zahid, Areesha Rashid, Habiba Mohsin, Asif Ghafoor, Shamaila Ishaq   +8 more
openalex   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source