Results 231 to 240 of about 5,700,393 (345)

Therapeutic Conservatism

Journal of the Royal College of Physicians of London, 1993
openaire   +4 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Gut-derived imidazole propionate promotes atherosclerosis through myeloid imidazoline-1 receptor signaling: new biomarker and therapeutic target. [PDF]

Signal Transduct Target Ther
Wang W, Semo D, Godfrey R.
europepmc   +1 more source

CERVICAL SPONDYLOSIS: PILOT THERAPEUTIC TRIAL [PDF]

, 1959
V. L. Steinberg, R. M. Mason
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Nasal vaccination against <i>Trypanosoma cruzi</i>: a dual approach for prevention and treatment of chronic Chagas cardiomyopathy. [PDF]

Front Immunol
Cacik P, Pacini MF, Bulfoni Balbi C, Dinatale B, Diaz G, Cha U, Farré C, Gianeselli M, Prochetto E, Peréz AR, Marcipar IS.   +10 more
europepmc   +1 more source

Therapeutic Assays of the Skin and Cancer Unit of the New York University Hospital

, 1951
Frances Pascher, H.H. Sawicky, Mabel G. Silverberg, M Braitman, Norman B. Kanof   +4 more
openalex   +1 more source

General Anaesthesia as an Aid to Therapeutic Hypothermia [PDF]

, 1957
James Parkhouse
openalex   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Gas-mediated reinforcement of cancer therapies: emerging strategies and future perspectives. [PDF]

Chem Sci
Yuan F, Wang L, Ning L, Zhang J, Guo Y.
europepmc   +1 more source