Results 31 to 40 of about 3,095,595 (149)

Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using competing inert hydroxymethylene diphosphonate

open access: yeseLife, 2022
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) presents as a morbid jawbone lesion in patients exposed to a nitrogen-containing bisphosphonate (N-BP). Although it is rare, BRONJ has caused apprehension among patients and healthcare providers and
Hiroko Okawa   +13 more
doaj   +1 more source

Therapeutic ultrasound

open access: yesUltrasound in Medicine & Biology, 1986
Currently the most widely applied use of therapeutic ultrasound in ophthalmology is for the treatment of refractory glaucoma. This new technique is described, histologic changes in experimental animals discussed, and mode of action postulated. The intraocular pressure (IOP) results obtained after treatment of 187 patient eyes are presented, with a ...
D J, Coleman   +6 more
openaire   +2 more sources

Macromolecular therapeutics [PDF]

open access: yesJournal of Controlled Release, 2014
This review covers water-soluble polymer-drug conjugates and macromolecules that possess biological activity without attached low molecular weight drugs. The main design principles of traditional and backbone degradable polymer-drug conjugates as well as the development of a new paradigm in nanomedicines - (low molecular weight) drug-free ...
Jiyuan, Yang, Jindřich, Kopeček
openaire   +2 more sources

Gelatin Sponge Particle Embolization of Spontaneously Ruptured Intrahepatic Arterial Aneurysms in a Patient with Polyarteritis Nodosa: A Case Report

open access: yes대한영상의학회지, 2017
Multiple intrahepatic arterial aneurysms and spontaneous aneurysmal rupture associated with polyarteritis nodosa leading to hemoperitoneum are extremely rare occurrences, but the conditions can be life-threatening if left untreated because of the risk of
Myung Jin Seol   +3 more
doaj   +1 more source

Blockade of LAG-3 Immune Checkpoint Combined With Therapeutic Vaccination Restore the Function of Tissue-Resident Anti-viral CD8+ T Cells and Protect Against Recurrent Ocular Herpes Simplex Infection and Disease

open access: yesFrontiers in Immunology, 2018
Recurrent viral diseases often occur after the viruses evade the hosts' immune system, by inducing exhaustion of antiviral T cells. In the present study, we found that functionally exhausted herpes simplex virus type 1 (HSV-1) -specific CD8+ T cells ...
Soumyabrata Roy   +11 more
doaj   +1 more source

Targeting matrix metalloproteases: A promising strategy for herbal medicines to treat rheumatoid arthritis

open access: yesFrontiers in Immunology, 2022
As a type of metalloproteinase, matrix metalloproteinases (MMPs) can be divided into collagenase, gelatinase, stromelysins, membrane-type (MT)-MMPs and heterogeneous subgroups according to their structure and function.
Ruo-Lan Li   +8 more
doaj   +1 more source

From Poison to Promise: The Evolution of Tetrodotoxin and Its Potential as a Therapeutic

open access: yesToxins, 2021
Tetrodotoxin (TTX) is a potent neurotoxin that was first identified in pufferfish but has since been isolated from an array of taxa that host TTX-producing bacteria.
Gary M. Bucciarelli   +5 more
doaj   +1 more source

Irisin protects against obesity-related chronic kidney disease by regulating perirenal adipose tissue function in obese mice

open access: yesLipids in Health and Disease, 2022
Background Compared with typical visceral fat deposits in obesity and metabolic syndrome, perirenal adipose tissue (PRAT) dysfunction is more closely linked to obesity-related chronic kidney disease (OB-CKD).
Fang Han   +8 more
doaj   +1 more source

Proteasome Inhibition Is an Effective Treatment Strategy for Microsporidia Infection in Honey Bees

open access: yesBiomolecules, 2021
The microsporidia Nosema ceranae is an obligate intracellular parasite that causes honey bee mortality and contributes to colony collapse. Fumagillin is presently the only pharmacological control for N. ceranae infections in honey bees.
Emily M. Huntsman   +5 more
doaj   +1 more source

Risk Factors for Liver Function Deterioration after Transarterial Chemoembolization Refractoriness in Child-Pugh Class A Hepatocellular Carcinoma Patients

open access: yesThe Korean Journal of Gastroenterology, 2020
Background/Aims: A switch to systemic therapy, such as sorafenib, should be considered for hepatocellular carcinoma (HCC) patients refractory to transarterial chemoembolization (TACE).
Kang Hyun Park   +10 more
doaj   +1 more source

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