Results 41 to 50 of about 5,632,141 (320)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Personality disorder and intellectual disability: the impacts of horticultural therapy within a medium-secure unit [PDF]

, 2016
This study was designed to explore the efficacy of a horticultural therapy intervention for the enhancement of subjective health and wellbeing in male service users with a dual diagnosis of personality disorder and intellectual disability in a medium ...
Christie, Mark, Cole, Fiona, Miller, Paul K., Thompson, Michaela   +3 more
core   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Comparison of the Efficacy and Safety of Transarterial Chemoembolization with or without Lenvatinib for Unresectable Hepatocellular Carcinoma: A Retrospective Propensity Score–Matched Analysis

Journal of Hepatocellular Carcinoma, 2022
Yu-Xing Chen,1,* Jin-Xing Zhang,1,* Chun-Gao Zhou,1 Jin Liu,2 Sheng Liu,1 Hai-Bin Shi,1 Qing-Quan Zu1 1Department of Interventional Radiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, People’s Republic of ...
Chen YX, Zhang JX, Zhou CG, Liu J, Liu S, Shi HB, Zu QQ   +6 more
doaj  

Processing the Therapeutic Relationship [PDF]

, 2009
The authors propose that if therapists and clients process their therapeutic relationship (i.e., directly address in the here and now feelings about each other and about the inevitable problems that emerge in the therapy relationship), feelings will be ...
Hill, Clara E, Knox, Sarah
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Predictive Factors for Complete Response and Recurrence after Transarterial Chemoembolization in Hepatocellular Carcinoma

Gut and Liver, 2017
Background/AimsTo investigate the predictive factors for complete response (CR) and recurrence after CR in patients with hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE).Methods : Among 691 newly diagnosed HCC patients ...
Shin Ok Jeong, Eui Bae Kim, Soung Won Jeong, Jae Young Jang, Sae Hwan Lee, Sang Gyune Kim, Sang Woo Cha, Young Seok Kim, Young Deok Cho, Hong Soo Kim, Boo Sung Kim, Yong Jae Kim, Dong Erk Goo, Su Yeon Park   +13 more
doaj   +1 more source

SOCIALLY MALADJUSTED – “THERAPEUTIC DIET” AS AN ALTERNATIVE THERAPEUTIC INTERVENTION [PDF]

Probacja, 2020
“The rapeutic Diet” is a proposal of alternative therapeutic intervention for the socially maladjusted youth. It assumes an impact on both psychological aspects and biological functioning of the youth through everyday rituals and habits connected with ...
Małgorzata Reiter, Magdalena Krzyżanowska, Patrycja Uram   +2 more
doaj   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

A quantitative study on the role of TKI combined with Wnt/$β$-catenin signaling and IFN-$α$ in the treatment of CML through deterministic and stochastic approaches [PDF]

, 2019
We propose deterministic and stochastic models for studying the pharmacokinetics of chronic myeloid leukemia (CML), upon administration of IFN-$\alpha$ (the traditional treatment for CML), TKI (the current frontline medication for CML) and Wnt/$\beta$-catenin signaling (the state-of-the art therapeutic breakthrough for CML).
arxiv   +1 more source