Results 131 to 140 of about 32,878,841 (350)
, 2023 Background:Recent studies have reported ethnic differences in vincristine exposure and outcomes such as toxicity. This resulted in the hypothesis of subtherapeutic dosing in African children.
Dorlo, Thomas P. C., +13 more
core +1 more source
Know your enemy: Nature and biochemistry of obesity [PDF]
Arhiv za farmacijuObesity represents a serious medical condition and has nowadays reached pandemic proportions. Comorbidities associated with obesity are severe, and affect almost all organ systems. Adipose tissue has several important functions: to provide energy storage,
Bjelanović Jasna, Skrobić Ognjan
doaj +1 more source
Diagnostic and therapeutic approach to infectious diseases in solid organ transplant recipients
Intensive Care Medicine, 2019 PurposePrognosis of solid organ transplant (SOT) recipients has improved, mainly because of better prevention of rejection by immunosuppressive therapies.
J. Timsit +16 more
semanticscholar +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito +7 more
wiley +1 more source
“I’ve Killed My Puppet!” A Relational Psychotherapeutic Approach to Inclusive Classroom Practices
Journal of Curriculum Theorizing, 2019 This article begins with a story called “I’ve killed my puppet” based on an incident that unfolded in the author’s university class, which provides a concrete illustration of the potential of a relational psychotherapeutic approach to inclusion.
Joseph Michael Valente
doaj +1 more source
Proteasome Activation as a New Therapeutic Approach To Target Proteotoxic Disorders
Journal of Medicinal Chemistry, 2019 Proteasomes are multienzyme complexes that maintain protein homeostasis (proteostasis) and important cellular functions through the degradation of misfolded, redundant, and damaged proteins.
Evert Njomen, J. Tepe
semanticscholar +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Pharmacological Targeting of Microglial Activation: New Therapeutic Approach
Frontiers in Cellular Neuroscience, 2019 Mounting evidence suggests that neuroinflammation is not just a consequence but a vital contributor to the development and progression of Parkinson’s disease (PD). Microglia in particular, may contribute to the induction and modulation of inflammation in
Cai-Yun Liu +3 more
semanticscholar +1 more source