Coolmine Therapeutic Community. A year of change: annual report 2006.
, 2007 The therapeutic community model is a treatment and rehabilitation approach where clients live in small structured drug-free communities. The goal is to encourage psychological and lifestyle changes to enable people to maintain a drug-free existence.
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The negative effects of dynamic psychotherapies based on the characteristics of the therapist, the therapist, and the treatment approach: a qualitative study. [PDF]
مجله علوم روانشناختیBackground: Just as different forms of dynamic psychotherapy can be considered as an effective tool for the treatment of mental disorders, it can also have negative effects. However, despite various studies, there have been few qualitative studies on the
hossein mohajeri +3 more
doaj
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
The Impact of Psychological Interventions and Pharmacotherapy on Improving Social Anxiety: A Systematic Review [PDF]
مجله علوم روانشناختیBackground: Social anxiety disorder, as one of the most common psychological disorders, is characterized by a persistent fear of negative evaluation in social and performance situations, significantly impacting the individual’s and social quality of life
Zahra Aboojasem +1 more
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Embedding Therapeutic Training in Teacher Education: building resilience in teachers [PDF]
Early career teachers are under considerable pressure and are expected to adjust quickly to the complex and demanding role of teaching. The percentage of teachers who leave the profession within the first five years is concerning (Carlyle and Woods, 2002;
Braine, Margaret, Turner, Sarah
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Community-based therapeutic care: treating severe acute malnutrition in sub-Saharan Africa [PDF]
, 2009 Severe acute malnutrition (SAM) affects approximately 13 million children under-five and is associated with over 1.5 million preventable child deaths each year.
Sadler, K.
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Maximizing Participation in Olfactory Training in a Sample with Post-COVID-19 Olfactory Loss
Brain SciencesPurpose: This study aims to highlight the feasibility of an olfactory training program entirely monitored through online media in COVID-19 patients. Methods: Classic olfactory training was performed with a sample with olfactory loss due COVID-19 (n = 11).
Alice Helena Delgado-Lima +2 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source