Results 161 to 170 of about 2,658,769 (310)

Real‑life diagnostic and therapeutic approach to CLL/SLL in tuscany: the 2025 consensus. [PDF]

Clin Exp Med
D'Amato M, Rapolla CM, Benedetti E, Bocchia M, Capochiani E, Carlomagno G, Ciofini S, Giachetti R, Maestrini G, Moretti S, Nasso D, Papini G, Pirrotta MT, Simonetti F, Santini S, Vannucchi A, Galimberti S, Sanna A.   +17 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Adipose-Derived Stem Cells as Therapeutic Approach in Hypertrophic Scar Formation-A Systematic Review. [PDF]

Int Wound J
Kohlhauser M, Lüttschwager S, Pignet AL, Schellnegger M, Moshammer M, Kamolz LP.   +5 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

ENPP1 inhibition as a therapeutic approach for later-onset hypophosphatasia. [PDF]

J Bone Miner Res
Narisawa S, Amadeu de Oliveira F, Tokuhara CK, Lira Dos Santos EJ, Fonfria E, Batson J, Cheng Z, Houston A, Foster BL, Millán JL.   +9 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Editorial: Emerging Therapeutic Approaches for Cystic Fibrosis

Frontiers in Pharmacology, 2019
Miquéias Lopes-Pacheco, Nicoletta Pedemonte, Anthony Kicic, Anthony Kicic, Anthony Kicic, Anthony Kicic   +5 more
doaj   +1 more source

Advanced Therapeutic Approach Based on LDHs-Mimetic Oxidoreductase. [PDF]

Adv Sci (Weinh)
Song K, Wei Y, Jia P, He S, Wang Q, Xu M, Liu H, Bao P, Guan S, Qu X.   +9 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Atypical Parathyroid Tumor: A Case Report on the Diagnostic and Therapeutic Approach. [PDF]

Cureus
Theofilopoulou S, Sidiropoulos T, Kokoropoulos P, Christodoulou S, Poulios E.   +4 more
europepmc   +1 more source