Results 51 to 60 of about 443,976 (213)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

PARENTING QUALITY IN DRUG-ADDICTED MOTHERS IN A THERAPEUTIC MOTHER-CHILD COMMUNITY: THE CONTRIBUTION OF ATTACHMENT AND PERSONALITY ASSESSMENT

Frontiers in Psychology, 2014
Growing evidence shows that attachment is a key risk factor for the diagnosis and treatment of clinical diseases in Axis I, such as drug addiction. Recent literature regarding attachment, psychiatric pathology and drug addiction demonstrates that there ...
Francesca eDe Palo, Nicoletta eCapra, Alessandra eSimonelli, Silvia eSalcuni, Daniela eDi Riso   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Integration of Hepatitis C and Addiction Treatment in People Who Inject Drugs: The San Patrignano HCV-Free and Drug-Free Experience

Viruses
Injection drug use represents an important contributor to hepatitis C virus (HCV) transmission, hence therapeutic communities (TCs) are promising points of care for the identification and treatment of HCV-infected persons who inject drugs (PWIDs).
Pierluca Piselli, Antonio Boschini, Romina Gianfreda, Alessandra Nappo, Claudia Cimaglia, Gianpaolo Scarfò, Camillo Smacchia, Raffaella Paoletti, Sarah Duehren, Enrico Girardi   +9 more
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Risk factors for mortality among kidney transplant recipients with COVID-19 in Saudi Arabia: a case-control study

BMC Infectious Diseases
Background The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has profoundly impacted global health, leading to over 74 million confirmed cases and 1.67 million deaths by December 2020. In Saudi Arabia, extensive measures were implemented
Dema A. Alissa, Rawan Almasuood, Baraa Alghalyini, Hala Tamim, Mohammed Alaa Raslan, Abdul Rehman Zia Zaidi, Bader Abou Shaar, Mhd Malek Al Masri, Adnan Abdul Karim, Wejdan Aburas, Waled Aburas, Ahmed H. Al-jedai, Reem S. Almaghrabi   +12 more
doaj   +1 more source

Bridging the gap between policy and practice: a qualitative analysis of providers’ field experiences tinkering with directly observed therapy in patients with drug-resistant tuberculosis in Addis Ababa, Ethiopia

BMJ Open, 2020
Objectives Drug-resistant tuberculosis (DR-TB) is one of the major public health threats in low-income countries such as Ethiopia. It is intertwined with larger socioeconomic and political factors that complicate its management and control.
Christoph Gradmann, Tsegahun Manyazewal, Kirubel Manyazewal Mussie   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A "reeducação" de adolescentes em uma comunidade terapêutica: o tratamento da drogadição em uma instituição religiosa

Psicologia: Teoria e Pesquisa
O abuso de drogas por adolescentes é, atualmente, um grave problema de saúde pública. Nessa área, a questão do tratamento destaca-se como um grande desafio, principalmente pelo fato de a maioria das intervenções não estar adaptada às especificidades ...
Luciane Marques Raupp, Clary Milnitisky-Sapiro   +1 more
doaj   +1 more source