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Therapeutic drug monitoring

Acta Neuropsychiatrica, 1999
SUMMARYThe cytochrome P450 iso-enzyme system plays a key role in the biotransformation of many drugs, including psychotropics. Its activity is determined by both genetic and environmental factors. The most important iso-enzymes for psychiatry in general are P450 IID6, 3A4 and 1A2.
J B, Noten   +3 more
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TDM: Therapeutic Drug Measuring or Therapeutic Drug Monitoring?

Therapeutic Drug Monitoring, 2005
The third round of the International Interlaboratory Quality Control Program for Therapeutic Drug Monitoring in HIV infection (QC-program) consisted of the analysis not only of plasma samples but also of patient cases. The case was composed of different topics related to the therapeutic drug monitoring of antiretroviral drugs.
Droste, J.A.H.   +3 more
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Office Therapeutic Drug Monitoring

Primary Care: Clinics in Office Practice, 1986
Considerations necessary for appropriate therapeutic drug monitoring in the office practice setting have been presented. Practical issues focusing on clinical pharmacokinetics as well as serum drug concentration evaluation methods and techniques have been reviewed, with emphasis on orally administered medications.
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Therapeutic Drug Monitoring of Antiarrhythmic Drugs

Clinical Pharmacokinetics, 2003
Most antiarrhythmic drugs fulfil the formal requirements for rational use of therapeutic drug monitoring, as they show highly variable plasma concentration profiles at a given dose and a direct concentration-effect relationship. Therapeutic ranges for antiarrhythmic drugs are, however, often very poorly defined.
Gesche, Jürgens   +2 more
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Antiepileptic Therapeutic Drug Monitoring

Clinics in Laboratory Medicine, 1981
The effort to employ therapeutic drug monitoring in the management of patients with convulsive disorders has been extremely successful. Fortunately, the drugs used by the majority of these patients are readily measured in plasma, and in most cases the plasma concentration is a valid measure of the appropriateness of the dosage of drug administered ...
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Antimicrobial Therapeutic Drug Monitoring

Clinics in Laboratory Medicine, 1981
Antimicrobial agents can be allergenic, have toxic effects on the function of certain organ systems, produce idiosyncratic reactions, alter the normal bacterial flora of the body, and adversely interact with other medications. All possible untoward side effects must be carefully monitored when prescribing antimicrobial agents.
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