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Therapeutic Drug Monitoring in Saliva
Clinical Pharmacokinetics, 1978The observation that drug concentrations in saliva are often proportional to the concentrations in plasma has led to the suggestion that in therapeutic drug monitoring, or in pharmacokinetic studies in general, saliva might be substituted for plasma.
M, Danhof, D D, Breimer
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Office Therapeutic Drug Monitoring
Primary Care: Clinics in Office Practice, 1986Considerations necessary for appropriate therapeutic drug monitoring in the office practice setting have been presented. Practical issues focusing on clinical pharmacokinetics as well as serum drug concentration evaluation methods and techniques have been reviewed, with emphasis on orally administered medications.
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Principles of therapeutic drug monitoring
Postgraduate Medicine, 1981Biochemical monitoring is generally advised for drugs that are potentially toxic, have a narrow therapeutic range, or are prescribed for life-threatening disease. Monitoring should not be attempted until the serum concentration reaches a plateau, or steady state, and sampling must be timed carefully.
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Antiepileptic Therapeutic Drug Monitoring
Clinics in Laboratory Medicine, 1981The effort to employ therapeutic drug monitoring in the management of patients with convulsive disorders has been extremely successful. Fortunately, the drugs used by the majority of these patients are readily measured in plasma, and in most cases the plasma concentration is a valid measure of the appropriateness of the dosage of drug administered ...
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Therapeutic drug monitoring in tuberculosis
European Journal of Clinical PharmacologyTherapeutic drug monitoring (TDM) is a standard clinical procedure that uses the pharmacokinetic and pharmacodynamic parameters of the drug in the body to determine the optimal dose. The pharmacokinetic variability of the drug(s) is a significant contributor to poor treatment outcomes, including the development of acquired drug resistance.
M, Sarkar, J, Sarkar
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Therapeutic Drug Monitoring in Pregnancy
Therapeutic Drug Monitoring, 2012Therapeutic drug monitoring (TDM) is commonly recommended to optimize drug dosing regimens of various medications. It has been proposed to guide therapy in pregnant women, in whom physiological changes may lead to altered pharmacokinetics resulting in difficulty in predicting the appropriate drug dosage.
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