Results 61 to 70 of about 1,472,669 (399)

Should we monitor psychotropic drug levels in pregnancy and the postpartum period to reduce risks of recurrence?

European Psychiatry, 2021
Pregnancy is associated with profound changes in pharmacokinetic processes. This is an important - and until recently neglected - area of research since the majority of women take drugs during pregnancy in addition to vitamin and dietary supplements ...
A. Wieck
doaj   +1 more source

Official International Association for Therapeutic Drug Monitoring and Toxicology guideline: Development and Validation of Dried Blood Spot-based Methods for Therapeutic Drug Monitoring.

Therapeutic Drug Monitoring, 2019
Dried blood spot (DBS) analysis has been introduced more and more into clinical practice to facilitate Therapeutic Drug Monitoring (TDM). To assure the quality of bioanalytical methods, the design, development and validation needs to fit the intended use.
S. Capiau, Herman Veenhof, R. Koster, Y. Bergqvist, M. Boettcher, O. Halmingh, B. Keevil, B. Koch, R. Linden, C. Pistos, L. Stolk, D. Touw, C. Stove, J. Alffenaar   +13 more
semanticscholar   +1 more source

Determination of itraconazole and hydroxyitraconazole in plasma by use of liquid chromatography-tandem mass spectrometry with on-line solid-phase extraction [PDF]

, 2003
In this paper a method for the simultaneous quantification of the anti-fungal drug itraconazole and its co-active metabolite hydroxyitraconazole in plasma employing liquid chromatography tandem-mass spectrometry and automated solid-phase extraction is ...
Schiel, Xaver, Spöhrer, Ute, Vogeser, Michael   +2 more
core   +1 more source

Monitoring of gentamicin blood level in one-week-of-life neonates admitted to a special care nursery ward

Gülhane Tıp Dergisi, 2022
Aims:Gentamicin is routinely used in neonates as an empirical antibiotic for suspected sepsis at a dose of 4.0 mg/kg, either 24 or 36 hourly based on premenstrual age. Regularly, therapeutic drug monitoring is performed.
Suzana Mustafa, Siti Latifah Azirah Mohd Noor, Rozitah Razman, Wan Nazirah Wan Yusuf   +3 more
doaj   +1 more source

Therapeutic drug monitoring of oral targeted antineoplastic drugs

European Journal of Clinical Pharmacology, 2020
This review provides an overview of the current challenges in oral targeted antineoplastic drug (OAD) dosing and outlines the unexploited value of therapeutic drug monitoring (TDM).
Anna Mueller‐Schoell, S. Groenland, Oliver Scherf-Clavel, M. van Dyk, W. Huisinga, R. Michelet, U. Jaehde, N. Steeghs, A. Huitema, C. Kloft   +9 more
semanticscholar   +1 more source

Ganciclovir therapeutic drug monitoring in transplant recipients

Journal of Antimicrobial Chemotherapy, 2021
Background The use of (val)ganciclovir is complicated by toxicity, slow response to treatment and acquired resistance. Objectives To evaluate a routine therapeutic drug monitoring (TDM) programme for ganciclovir in a transplant patient population ...
A. Märtson, A. E. Edwina, J. Burgerhof, S. Berger, Anoek A. E. de Joode, K. Damman, E. Verschuuren, H. Blokzijl, Martijn Bakker, L. Span, T. S. van der Werf, D. Touw, M. Sturkenboom, M. Knoester, J. C. Alffenaar   +14 more
semanticscholar   +1 more source

Pharmacometrics modeling and simulation to assist phenobarbital dose optimization in dogs

Frontiers in Veterinary Science
IntroductionPhenobarbital (PB) remains the first-line treatment for canine epilepsy due to its efficacy, affordability, and favorable pharmacokinetics.
Silvana Alvariza, Manuel Ibarra, Natalia Guevara, Cecilia Maldonado, Marta Vázquez, Gimena Feijoó, Gonzalo Suárez   +6 more
doaj   +1 more source

The Steps to Therapeutic Drug Monitoring: A Structured Approach Illustrated With Imatinib

Frontiers in Pharmacology, 2020
Pharmacometric methods have hugely benefited from progress in analytical and computer sciences during the past decades, and play nowadays a central role in the clinical development of new medicinal drugs.
T. Buclin, Yann Thoma, Nicolas Widmer, P. André, M. Guidi, C. Csajka, L. Decosterd   +6 more
semanticscholar   +1 more source

Quantification of voriconazole in plasma by liquid chromatography-tandem mass spectrometry [PDF]

, 2005
A convenient liquid chromatography-tandem mass spectrometry method for the quantification of the triazole antifungal agent voriconazole in plasma samples is described. Fenbuconazole is used as an internal standard.
Boyd, Denning, Dooley, Gage, Glasmacher, Hyland, Johnson, Keevil, Ozawa, Pennick, Potoski, Roffey, Stopher, Trifilio, Vogeser, Vogeser, Vogeser   +16 more
core   +1 more source

Medication Complications in Extracorporeal Membrane Oxygenation. [PDF]

, 2017
The need for extracorporeal membrane oxygenation (ECMO) therapy is a marker of disease severity for which multiple medications are required. The therapy causes physiologic changes that impact drug pharmacokinetics.
Aebi, Ami G. Shah, Anderson, Arlt, Barr, Barthelemy, Beiderlinden, Bein, Bembea, Bhatt-Meht, Boucher, Brandi N. Thoma, Brown, Buck, Buscher, Chung, Dagan, Dagan, de Montmollin, De Rosa, DeGrado, Donadello, Donadello, Dzierba, Erstad, Esper, Eyler, Flordelis Lasierra, Glauber, Greenberg, Gélisse, Hadidi, Hertzog, Hraiech, Hynynen, Johnston, Kawada, Kim, Koster, Krueger, Lamarche, Latronico, Lemaitre, Levison, Malfertheiner, Mehta, Michelle Peahota, Moore, Mousavi, Mulla, Mulla, Muntean, Oliver, Paden, Park, Perkins, Peters, Pettignano, Phillips, Pieri, Potter, Preston, Protti, Ranucci, Riker, Roberts, Roos, Rosen, Ruiz, Rybak, Saini, Sanfilippo, Satyapriya, Schmith, Shekar, Shekar, Shekar, Shekar, Shekar, Sherwin, Sklar, Smith, Spriet, Staudacher, Strunk, Subramaniam, Szefner, Tellor, Trudzinski, Tulman, Turner, Veinstein, Vilay, Wagner, Walter K. Kraft, Welsch, Wen, Wildschut, Wu, Young   +99 more
core   +2 more sources