Therapeutic Drug Monitoring in Non-Tuberculosis Mycobacteria Infections
Clinical Pharmacokinetics, 2021 Nontuberculous mycobacteria can cause minimally symptomatic self-limiting infections to progressive and life-threatening disease of multiple organs. Several factors such as increased testing and prevalence have made this an emerging infectious disease ...
J. Alffenaar +14 more
semanticscholar +1 more source
An aptamer-biosensor for azole class antifungal drugs [PDF]
, 2017 This report describes the development of an aptamer for sensing azole antifungal drugs for therapeutic drug monitoring. Modified Synthetic Evolution of Ligands through Exponential Enrichment (SELEX) was used to discover a DNA aptamer recognizing azole class antifungal drugs.
arxiv +1 more source
Optical Biosensors for Therapeutic Drug Monitoring
Biosensors, 2019 Therapeutic drug monitoring (TDM) is a fundamental tool when administering drugs that have a limited dosage or high toxicity, which could endanger the lives of patients.
Vivian Garzón +4 more
doaj +1 more source
Design and Analysis of a Sample-and-Hold CMOS Electrochemical Sensor for Aptamer-based Therapeutic Drug Monitoring [PDF]
arXiv, 2020 In this paper, we present the design and the analysis of an electrochemical circuit for measuring the concentrations of therapeutic drugs using structure-switching aptamers. Aptamers are single-stranded nucleic acids, whose sequence is selected to exhibit high affinity and specificity toward a molecular target, and change its conformation upon binding.
arxiv
Therapeutic algebra of immunomodulatory drug responses at single-cell resolution [PDF]
arXiv, 2022 Therapeutic modulation of immune states is central to the treatment of human disease. However, how drugs and drug combinations impact the diverse cell types in the human immune system remains poorly understood at the transcriptome scale. Here, we apply single-cell mRNA-seq to profile the response of human immune cells to 502 immunomodulatory drugs ...
arxiv
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Development of a Machine Learning Model and Mobile Application to Aid in Predicting Dosage of Vitamin K Antagonists Among Indian Patients [PDF]
arXiv, 2020 Patients who undergo mechanical heart valve replacements or have conditions like Atrial Fibrillation have to take Vitamin K Antagonists (VKA) drugs to prevent coagulation of blood. These drugs have narrow therapeutic range and need to be very closely monitored due to life threatening side effects.
arxiv
A continued learning approach for model-informed precision dosing: updating models in clinical practice [PDF]
arXiv, 2021 Model-informed precision dosing (MIPD) is a quantitative dosing framework that combines prior knowledge on the drug-disease-patient system with patient data from therapeutic drug/ biomarker monitoring (TDM) to support individualized dosing in ongoing treatment.Structural models and prior parameter distributions used in MIPD approaches typically build ...
arxiv
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Where next for antiepileptic therapeutic drug monitoring? [PDF]
Vojnosanitetski Pregled, 2019 nema
Janković Slobodan M.
doaj +1 more source