Results 41 to 50 of about 417,988 (310)

Therapeutic Drug Monitoring of Antibiotics Is Needed in the Treatment of Sepsis

Вестник анестезиологии и реаниматологии, 2022
The article presents the results of a prospective one-center observational clinical study.The level of therapeutic drug monitoring antibiotics was studied in patients with sepsis.The objective: to assess the impact of pharmacokinetics and ...
G. P. Plotnikov, A. N. Kudryavtsev, A. A. Kleuzovich, A. G. Chizhov, A. A. Ponomarev, S. S. Larin, E. A. Litvin, L. A. Anastasevich   +7 more
doaj   +1 more source

Therapeutic Drug Monitoring of Voriconazole [PDF]

Therapeutic Drug Monitoring, 2008
Voriconazole is a triazole antifungal developed for the treatment of life-threatening fungal infections in immunocompromised patients. The drug, which is available for both oral and intravenous administration, has broad-spectrum activity against pathogenic yeasts, dimorphic fungi, and opportunistic molds.
Bruggemann, R.J.M., Donnelly, J.P., Aarnoutse, R.E., Warris, A., Blijlevens, N.M.A., Mouton, J.W., Verweij, P.E., Burger, D.M.   +7 more
openaire   +3 more sources

Therapeutic drug monitoring in Turkey: Experiences from Istanbul

, 2000
Therapeutic drug monitoring (TDM) has assumed an important place in patient management in the last few decades. In this study, serum drug levels determined in 7759 specimens sent to the Department of Pharmacology and Clinical Pharmacology in 1994 and ...
OZEK, Mehmet, Yamanturk, P, EROGLU, Lütfiye, SEVGI, S   +3 more
core   +1 more source

Monitoring of gentamicin blood level in one-week-of-life neonates admitted to a special care nursery ward

Gülhane Tıp Dergisi, 2022
Aims:Gentamicin is routinely used in neonates as an empirical antibiotic for suspected sepsis at a dose of 4.0 mg/kg, either 24 or 36 hourly based on premenstrual age. Regularly, therapeutic drug monitoring is performed.
Suzana Mustafa, Siti Latifah Azirah Mohd Noor, Rozitah Razman, Wan Nazirah Wan Yusuf   +3 more
doaj   +1 more source

Posaconazole therapeutic drug monitoring in a regional hospital setting

, 2016
Background: Posaconazole therapeutic drug monitoring (TDM) is recommended to promote effective antifungal prophylaxis, but its utility has yet to be optimized. Breakthrough invasive fungal infections have been reported with serum concentrations
Patrick J. Lindsay, Norris, Ross, Stuart E. Bond, Spiros Miyakis, Deborah J. E. Marriott, Marriott, Deborah JE, Bond, Stuart E., Miyakis, Spiros, Lindsay, Patrick J, Ross Norris   +9 more
core   +1 more source

Should we monitor psychotropic drug levels in pregnancy and the postpartum period to reduce risks of recurrence?

European Psychiatry, 2021
Pregnancy is associated with profound changes in pharmacokinetic processes. This is an important - and until recently neglected - area of research since the majority of women take drugs during pregnancy in addition to vitamin and dietary supplements ...
A. Wieck
doaj   +1 more source

Bioanalysis of racemic reboxetine and its desethylated metabolite in a therapeutic drug monitoring setting using solid phase extraction and HPLC

, 2001
Reboxetine isa new antidepressant drug acting as a potent and selective noradrenaline reuptake inhibitor on the noradrenergic neuronal system. Because of an expected interindividual variability in drug metabolism in the clinical practice the need for ...
Peterson, Curt,, Öhman, Daniel,, Bengtsson, Finn,, Norlander, Björn,   +3 more
core   +1 more source

Therapeutic Drug Monitoring of Antibody Drugs

Biological and Pharmaceutical Bulletin, 2022
In recent years, many antibody drugs that play an important role in the pharmacotherapy of several diseases have been developed. Antibody drugs exhibit immunogenicity in vivo leading to the development of antibodies against the antibody drug (anti-drug antibody). Nonetheless, other factors also affect the pharmacokinetics of antibody drugs.
openaire   +2 more sources

Pharmacometrics modeling and simulation to assist phenobarbital dose optimization in dogs

Frontiers in Veterinary Science
IntroductionPhenobarbital (PB) remains the first-line treatment for canine epilepsy due to its efficacy, affordability, and favorable pharmacokinetics.
Silvana Alvariza, Manuel Ibarra, Natalia Guevara, Cecilia Maldonado, Marta Vázquez, Gimena Feijoó, Gonzalo Suárez   +6 more
doaj   +1 more source

Therapeutic and toxic blood concentrations of nearly 1,000 drugs and other xenobiotics [PDF]

, 2012
Introduction: In order to assess the significance of drug levels measured in intensive care medicine, clinical and forensic toxicology, as well as for therapeutic drug monitoring, it is essential that a comprehensive collection of data is readily ...
Schulz, Martin, Andresen, Hilke, Achim Schmoldt, Stefanie Iwersen-Bergmann, Martin Schulz, Schmoldt, Achim, Iwersen-Bergmann, Stefanie, Hilke Andresen   +7 more
core   +1 more source